Virtual

Simple mathematical models have had remarkable successes in biology, framing how we understand a host of mechanisms and processes. However, with the advent of a host of new experimental technologies, the last ten years has seen an explosion in the amount and types of quantitative data now being generated. This sets a new challenge for the field – to develop, calibrate and analyse new, biologically realistic models to interpret these data. In this talk I will showcase how quantitative comparisons between models and data can help tease apart subtle details of biological mechanisms, as well as present some steps we have taken to tackle the mathematical challenges in developing models that are both identifiable and can be efficiently calibrated to quantitative data.

In this talk I will review the work that has been done by me, N. Gromov, V. Kazakov, G. Korchemsky and G. Sizov on the analysis of fishnet Feynman graphs in a particular scaling limit of $\mathcal N=4$ SYM, a theory dubbed $\chi$FT$_4$. After introducing said theory, in which the Feynman graphs take a very simple fishnet form — in the planar limit — I will review how to exploit integrable techniques to compute these graphs and, consequently, extract the anomalous dimensions of a simple class of operators.

I will lead an informal discussion centered on discrete data that need to be specified when reducing 6d relative theories on an internal manifold M and how they determine symmetries of the resulting theory T[M].

Amy Kent

Multiscale Mathematical Models for Tendon Tissue Engineering

Tendon tissue engineering aims to grow functional tendon in vitro. In bioreactor chambers, cells growing on a solid scaffold are fed with nutrient-rich media and stimulated by mechanical loads. The Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences is developing a Humanoid Robotic Bioreactor, where cells grow on a flexible fibrous scaffold actuated by a robotic shoulder. Tendon cells modulate their behaviour in response to shear stresses - experimentally, it is desirable to design robotic loading regimes that mimic physiological loads. The shear stresses are generated by flowing cell media; this flow induces deformation of the scaffold which in turn modulates the flow. Here, we capture this fluid-structure interaction using a homogenised model of fluid flow and scaffold deformation in a simplified bioreactor geometry. The homogenised model admits analytical solutions for a broad class of forces representing robotic loading. Given the solution to the microscale problem, we can determine microscale shear stresses at any point in the domain. In this presentation, we will outline the model derivation and discuss the experimental implications of model predictions.

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Michael Negus

High-Speed Droplet Impact Onto Deformable Substrates: Analysis And Simulations

The impact of a high-speed droplet onto a substrate is a highly non-linear, multiscale phenomenon and poses a formidable challenge to model. In addition, when the substrate is deformable, such as a spring-suspended plate or an elastic sheet, the fluid-structure interaction introduces an additional layer of complexity. We present two modeling approaches for droplet impact onto deformable substrates: matched asymptotics and direct numerical simulations. In the former, we use Wagner's theory of impact to derive analytical expressions which approximate the behaviour during the early stages of the impact. In the latter, we use the open source volume-of-fluid code Basilisk to conduct direct numerical simulations designed to both validate the analytical framework and provide insight into the later times of impact. Through both methods, we are able to observe how the properties of the substrate, such as elasticity, affect the behaviour of the flow. We conclude by showing how these methods are complementary, as a combination of both can lead to a thorough understanding of the droplet impact across timescales.

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Edwina Yeo

Modelling of Magnetically Targeted Stem Cell Delivery

Targeting delivery of stem cells to the site of an injury is a key challenge in regenerative medicine. One possible approach is to inject cells implanted withmagnetic nanoparticles into the blood stream. Cells can then be targeted to the delivery site by an external magnetic field. At the injury site, it is of criticalimportance that the cells do not form an aggregate which could significantly occlude the vessel.We develop a model for the transport of magnetically tagged cells in blood under the action of an external magnetic field. We consider a system of blood and stem cells in a single vessel.  We exploit the small aspect ratio of the vessel to examine the system asymptotically. We consider the system for a range of magnetic field strengths and varying strengths of the diffusion coefficient of the stem cells. We explore the different regimes of the model and determine the optimal conditions for the effective delivery of stem cells while minimising vessel occlusion.

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Helen Zha

Mathematical model of a valve-controlled, gravity driven bioreactor for platelet production

Hospitals sometimes experience shortages of donor blood platelet supplies, motivating research into~\textit{in vitro}~production of platelets. We model a novel platelet bioreactor described in Shepherd et al [1]. The bioreactor consists of an upper channel, a lower channel, and a cell-seeded porous collagen scaffold situated between the two. Flow is driven by gravity, and controlled by valves on the four inlets and outlets. The bioreactor is long relative to its width, a feature which we exploit to derive a lubrication reduction of unsteady Stokes flow coupled to Darcy. As the shear stress experienced by cells influences platelet production, we use our model to quantify the effect of varying pressure head and valve dynamics on shear stress.

[1] Shepherd, J.H., Howard, D., Waller, A.K., Foster, H.R., Mueller, A., Moreau, T., Evans, A.L., Arumugam, M., Chalon, G.B., Vriend, E. and Davidenko, N., 2018. Structurally graduated collagen scaffolds applied to the ex vivo generation of platelets from human pluripotent stem cell-derived megakaryocytes: enhancing production and purity. Biomaterials.

The Drinfeld half-plane is a rigid analytic variety over a p-adic field. In this talk, I will give an overview of the geometric aspects of this space and describe its connection with representation theory.

We consider weakly-coupled QFT in AdS at finite temperature. We compute the holographic thermal two-point function of scalar operators in the boundary theory. We present analytic expressions for leading corrections due to local quartic interactions in the bulk, with an arbitrary number of derivatives and for any number of spacetime dimensions. The solutions are fixed by judiciously picking an ansatz and imposing consistency conditions. The conditions include analyticity properties, consistency with the operator product expansion, and the Kubo-Martin-Schwinger condition. For the case without any derivatives we show agreement with an explicit diagrammatic computation. The structure of the answer is suggestive of a thermal Mellin amplitude. Additionally, we derive a simple dispersion relation for thermal two-point functions which reconstructs the function from its discontinuity.

I will review recent works on geometries underlying scattering amplitudes of (certain generalizations of) particles and strings  Tree amplitudes of a cubic scalar theory are given by "canonical forms" of the so-called ABHY associahedra defined in kinematic space. The latter can be naturally extended to generalized associahedra for finite-type cluster algebra, and for classical types their canonical forms give scalar amplitudes through one-loop order. We then consider vast generalizations of string amplitudes dubbed “stringy canonical forms”, and in particular "cluster string integrals" for any Dynkin diagram, which for type A reduces to usual string amplitudes. These integrals enjoy remarkable factorization properties at finite $\alpha'$, obtained simply by removing nodes of the Dynkin diagram; as $\alpha'\rightarrow 0$ they reduce to canonical forms of generalized associahedra, or the aforementioned tree and one-loop scalar amplitudes.

I will give an introduction to semigroup C*-algebras of ax+b-semigroups over rings of algebraic integers in algebraic number fields, a class of C*-algebras that was introduced by Cuntz, Deninger, and Laca. After explaining the construction, I will briefly discuss the state-of-the-art for this example class: These C*-algebras are unital, separable, nuclear, strongly purely infinite, and have computable primitive ideal spaces. In many cases, e.g., for Galois extensions, they completely characterise the underlying algebraic number field.