Mon, 20 Nov 2023
15:30
Lecture Theatre 3, Mathematical Institute, Radcliffe Observatory Quarter, Woodstock Road, OX2 6GG

SPDEs driven by standard symmetric α-stable cylindrical processes

Professor Markus Riedle
(Kings’ College London)
Abstract

Standard symmetric α-stable cylindrical processes in Hilbert spaces are the natural generalisation of the analogue processes in Euclidean spaces. However, like standard Brownian motions, standard symmetric α-stable processes in finite dimensions can only be generalised to infinite dimensional Hilbert spaces as cylindrical processes, i.e. processes in a generalised sense (of Gelfand and Vilenkin (1964) or Segal (1954))  not attaining values in the underlying Hilbert space.

In this talk, we briefly introduce the theory of stochastic integrals with respect to standard symmetric α-stable cylindrical processes. As these processes exist only in the generalised sense, introducing a stochastic integral requires an approach different to the classical one by semi-martingale decomposition. The main result presented in this talk is the existence of a solution to an abstract evolution equation driven by a standard symmetric α-stable cylindrical process. The main tool for establishing this result is a Yosida approximation and an Itô formula for Hilbert space-valued semi-martingales where the martingale part is represented as an integral driven by cylindrical α-stable noise. While these tools are standard in stochastic analysis, due to the cylindrical nature of our noise, their application requires completely novel arguments and techniques.

Fri, 19 Nov 2021

14:00 - 15:00
L3

Predicting atrial fbrillation treatment outcomes through mathematical modelling, signal processing and machine learning

Dr Caroline Roney
(Kings’ College London)
Abstract

Catheter ablation and antiarrhythmic drug therapy approaches for treatment of atrial fibrillation are sub-optimal. This is in part because it is challenging to predict long-term response to therapy from short-term measurements, which makes it difficult to select optimal patient-specific treatment approaches. Clinical trials identify patient demographics that provide prediction of long-term response to standard treatments across populations. Patient-specific biophysical models can be used to assess novel treatment approaches but are typically applied in small cohorts to investigate the acute response to therapies. Our overall aim is to use machine learning approaches together with patient-specific biophysical simulations to predict long-term atrial fibrillation recurrence after ablation or drug therapy in large populations.

In this talk I will present our methodology for constructing personalised atrial models from patient imaging and electrical data; present results from biophysical simulations of ablation treatment; and finally explain how we are combining these methodologies with machine learning techniques for predicting long-term treatment outcomes.

 

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