North Meets South
Abstract
Title: Exploring the space of genes in single cell transcriptomics datasets
Abstract: Single cell transcriptomics is a revolutionary technique in biology that allows for the measurement of gene expression levels across the genome for many individual cells simultaneously. Analysis of these vast datasets reveals variations in expression patterns between cells that were previously out of reach. On top of discrete clustering into cell types, continuous patterns of variation become visible, which are associated to differentiation pathways, cell cycle, response to treatment, adaptive heterogeneity or what just whatever the cells are doing at that moment. Current methods for assigning biological meaning to single cell experiments relies on predefining groups of cells and computing what genes are differentially expressed between them. The complexity found in modern single cell transcriptomics datasets calls for more intricate methods to biologically interpret both discrete clusters as well as continuous variations. We propose topologically-inspired data analysis methods that identify coherent gene expression patterns on multiple scales in the dataset. The multiscale methods consider discrete and continuous transcriptional patterns on equal footing based on the mathematics of spectral graph theory. As well as selecting important genes, the methodology allows one to visualise and explore the space of gene expression patterns in the dataset.
Pitching soap films
Abstract
This talk is about the mathematics behind an artistic project focusing on the vibrations of soap films.
Bach, the Universe & Everything - The Mathematics of Decisions
Oxford Mathematics in partnership with Orchestra of the Age of Enlightenment - Bach, the Universe & Everything
The Mathematics of Decisions
Sunday 20 March, 5:30-6.30pm
Mathematical Institute, OX2 6GG
The Science:
In this talk, Oxford Mathematics's Samuel Cohen asks: how do you make decisions today when you know things will change tomorrow?
The Music:
JS Bach: Liebster Jesu, mein Verlangen (Dearest Jesus, my Desire, BWV 32)
This Cantata is in the form of a dialogue. It reminds us of what we have lost and what we can find.
JS Bach: Prelude, Freu dich sehr, o meine Seele (BWV Anh. II 52)
William Byrd: Christe qui lux es et dies
Tomaso Albinoni: Adagio from Oboe Concerto Op 9 No. 2
Tickets £15: Buy tickets here
When machine learning deciphers the 'language' of atmospheric air masses
Abstract
Latent Dirichlet Allocation (LDA) is capable of analyzing thousands of documents in a short time and highlighting important elements, recurrences and anomalies. It is generally used in linguistics to study natural language: its word analysis reveals the theme(s) of a document, each theme being identified by a specific vocabulary or, more precisely, by a particular statistical distribution of word frequency.
In the climatologists' use of LDA, the document is a daily weather map and the word is a pixel of the map. The theme with its corpus of words can become a cyclone or an anticyclone and, more generally, a 'pattern' that the scientists term motif. Artificial intelligence – a sort of incredibly fast robot meteorologist – looks for correlations both between different places on the same map, and between successive maps over time. In a sense, it 'notices' that a particular location is often correlated with another location, recurrently throughout the database, and this set of correlated locations constitutes a specific pattern.
The algorithm performs statistical analyses at two distinct levels: at the word or pixel level of the map, LDA defines a motif, by assigning a certain weight to each pixel, and thus defines the shape and position of the motif; LDA breaks down a daily weather map into all these motifs, each of which is assigned a certain weight.
In concrete terms, the basic data are the daily weather maps between 1948 and nowadays over the North Atlantic basin and Europe. LDA identifies a dozen or so spatially defined motifs, many of which are familiar meteorological patterns such as the Azores High, the Genoa Low or even the Scandinavian Blocking. A small combination of those motifs can then be used to describe all the maps. These motifs and the statistical analyses associated with them allow researchers to study weather phenomena such as extreme events, as well as longer-term climate trends, and possibly to understand their mechanisms in order to better predict them in the future.
The preprint of the study is available as:
Lucas Fery, Berengere Dubrulle, Berengere Podvin, Flavio Pons, Davide Faranda. Learning a weather dictionary of atmospheric patterns using Latent Dirichlet Allocation. 2021. ⟨hal-03258523⟩ https://hal-enpc.archives-ouvertes.fr/X-DEP-MECA/hal-03258523v1
Hydrodynamics of swimming bacteria: reorientation during tumbles and viscoelastic lift
Abstract
Bacteria represent the major component of the world’s biomass. A number of these bacteria are motile and swim with the use of flagellar filaments, which are slender helical appendages attached to a cell body by a flexible hook. Low Reynolds number hydrodynamics is the key for flagella to generate propulsion at a microscale [1]. In this talk I will discuss two projects related to swimming of a model bacterium Escherichia coli (E. coli).
E. coli has many flagellar filaments that are wrapped in a bundle and rotate in a counterclockwise fashion (if viewed from behind the cell) during the so-called ‘runs’, wherein the cell moves steadily forward. In between runs, the cell undergoes quick ‘tumble’ events, during which at least one flagellum reverses its rotation direction and separates from the bundle, resulting in erratic motion in place. Alternating between runs and tumbles allows cells to sample space by stochastically changing their propulsion direction after each tumble. In the first part of the talk, I will discuss how cells reorient during tumble and the mechanical forces at play and show the predominant role of hydrodynamics in setting the reorientation angle [2].
In the second part, I will talk about hydrodynamics of bacteria near walls in visco-elastic fluids. Flagellar motility next to surfaces in such fluids is crucial for bacterial transport and biofilm formation. In Newtonian fluids, bacteria are known to accumulate near walls where they swim in circles [3,4], while experimental results from our collaborators at the Wu Lab (Chinese University of Hong Kong) show that in polymeric liquids this accumulation is significantly reduced. We use a combination of analytical and numerical models to propose that this reduction is due to a viscoelastic lift directed away from the plane wall induced by flagellar rotation. This viscoelastic lift force weakens hydrodynamic interaction between flagellated swimmers and nearby surfaces, which results in a decrease in surface accumulation for the cells.
References
[1] Lauga, Eric. "Bacterial hydrodynamics." Annual Review of Fluid Mechanics 48 (2016): 105-130.
[2] Dvoriashyna, Mariia, and Eric Lauga. "Hydrodynamics and direction change of tumbling bacteria." Plos one 16.7 (2021): e0254551.
[3] Berke, Allison P., et al. "Hydrodynamic attraction of swimming microorganisms by surfaces." Physical Review Letters 101.3 (2008): 038102.
[4] Lauga, Eric, et al. "Swimming in circles: motion of bacteria near solid boundaries." Biophysical journal 90.2 (2006): 400-412.
18:30
Castalian String Quartet - Mozart & Mendelssohn
As part of our partnership with the Faculty of Music in Oxford, we are delighted to welcome the Castalian String Quartet to the Andrew Wiles Building. The Quartet holds the Hans Keller String Quartet Residency at the Faculty of Music for the academic years 2021-24.
Mozart - String Quartet No. 15 in D minor, K. 421
Fanny Mendelssohn - String Quartet in E flat major
Interval
Felix Mendelssohn – String Quartet No. 6 in F minor, Op. 80
The Castalian String Quartet presents a programme of three string quartets from Viennese composers. Starting with one of Mozart's quartet tributes to Haydn, his String Quartet No. 15 in D minor; this is followed by one of the earliest known string quartets written by a woman composer, Fanny Mendelssohn's String Quartet in E flat major; and ending with Felix Mendelssohn’s final String Quartet, his last major work, powerful and tempestuous.
The concert will be preceded by a talk by Dr Sebastian Wedler at 6.30pm. The concert will start at 7.30pm.
Mathematical Institute, Woodstock Road, Oxford OX2 6GG.
Tickets £15, free entry for all under 21s. Book tickets here.
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Preparing for Prelims and Part A exams
Abstract
Preparing for Prelims and Part A exams with Dr Vicky Neale
Description: This session will offer guidance for Prelims and Part A students preparing for closed-book, in-person exams this summer, with tips on revision and information about practical arrangements. If you have questions, please send them in advance (by 28 February) via https://vevox.app/#/m/170975861 and we'll try to address as many as possible during the session.
A separate session in Week 6 will be aimed at students doing Part B, Part C and MSc exams.
Preparing for Prelims and Part A exams
This session will offer guidance for Prelims and Part A students preparing for closed-book, in-person exams this summer, with tips on revision and information about practical arrangements. If you have questions, please send them in advance (by 28 February) via https://vevox.app/#/m/170975861 and we'll try to address as many as possible during the session.
A separate session in Week 6 will be aimed at students doing Part B, Part C and MSc exams.
Preparing for exams with A4 summary sheets
This session will offer some tips on preparing the A4 summary sheets permitted for Part B, Part C and MSc exams this summer. It will also include wider advice about preparing for and sitting in-person exams. If you have questions, please do send them in advance (by 21 February) via https://vevox.app/#/m/174169279 and we'll try to address as many as possible during the session.
This session is aimed at Part B, Part C and MSc students sitting exams this summer. A separate session in Week 7 will be aimed at Prelims and Part A students.
12:45
The uses of lattice topological defects
Abstract
Great progress has been made recently in exploiting categorical/topological/higher symmetries in quantum field theory. I will explain how the same structure is realised directly in the lattice models of statistical mechanics, generalizing Kramers-Wannier duality to a wide class of models. In particular, I will give an overview of my work with Aasen and Mong on using fusion categories to find and analyse lattice topological defects in two and 1+1 dimensions. These defects possess a variety of remarkable properties. Not only is the partition function is independent of deformations of their path, but they can branch and fuse in a topologically invariant fashion. The universal behaviour under Dehn twists gives exact results for scaling dimensions, while gluing a topological defect to a boundary allows universal ratios of the boundary g-factor to be computed exactly on the lattice. I also will describe how terminating defect lines allows the construction of fractional-spin conserved currents, giving a linear method for Baxterization, I.e. constructing integrable models from a braided tensor category.