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In recent years, methods and concepts of algebraic geometry, particularly those of real and computational algebraic geometry, have been used in many applied domains. In this talk, aimed at a broad audience, I will review applications to molecular biology. The goal is to analyze standard models in systems biology to predict dynamic behavior in regions of parameter space without the need for simulations. I will also mention some challenges in the field of real algebraic geometry that arise from these applications.

Predictive scoring modelling is a common approach to measure financial health and credit worthiness in banking. Whilst the latter is a key factor in making decisions for lending, evaluating financial health helps to identify vulnerable customers trending towards financial hardship, who need support. The current macroeconomic uncertainties amplify the importance of extensive flexibility in modelling data solutions so that they can remain effective and adaptive to a volatile economic environment. This workshop is focused on discussing relevant techniques and mathematical methodologies which can help modernise traditional scoring models and accelerate innovation. In summary, the problem definition in the banking context is how automation and optimality can be achieved in a multiobjective problem where a subset of existing data features should be selected by relevance and uniqueness, assigned scoring weights by importance and how a pool of customers can be categorised accordingly using their individual scores and auto-adjusting thresholds of risk classification scales. The key challenge is imposed by the mutual dependency of the three sub-problems and their objectives. Introducing or removing constraints in any of them can change the feasibility and optimality of the others and the overall solution. It is common for traditional scoring models to be mainly focused on the predictive accuracy and their setup is often defined and revised manually, following ad-hoc exploratory data analysis and business-led decision making. An automated optimisation of the data features’ selection, scoring weights and classification thresholds definition can achieve respectively: ▪ Precise financial health evaluation and book classification under changing economic climate; ▪ Development of innovative data-driven solutions to enhance prevention from financial hardship and bankruptcies.

I will discuss how to place conformal boundary conditions on free higher derivative theories of scalars and spinors as well as the zoo of boundary renormalization group flows that connect the different boundary conditions.  Historically, there are connections to Poisson’s ratio and classical equations governing the bending of thin steel plates.  As these higher derivative theories are often invoked in the context of cosmology, there may be cosmological applications for the boundary conditions discussed here.
 

The classical model of evaporation of liquids hinges on Maxwell’s assumption that the air near the liquid’s surface is saturated. It allows one to find the evaporative flux without considering the interface separating liquid and air. Maxwell’s hypothesis is based on an implicit assumption that the vapour-emission capacity of the interface exceeds the throughput of air (i.e., its ability to pass the vapour on to infinity). If indeed so, the air adjacent to the liquid would get quickly saturated, justifying Maxwell’s hypothesis.

In the present paper, the so-called diffuse-interface model is used to account for the interfacial physics and, thus, derive a generalised version of Maxwell’s boundary condition for the near-interface vapour density. It is then applied to a spherical drop floating in air. It turns out that the vapour-emission capacity of the interface exceeds the throughput of air only if the drop’s radius is r_d ≳ 10μm, but for r_d ≈ 2μm, the two are comparable. For r_d ≲ 1μm, evaporation is interface-driven, and the resulting evaporation rate is noticeably smaller than that predicted by the classical model.

Recent advances in experimental techniques have enabled remarkable discoveries and insight into how the dynamics of thin gas/vapour films can profoundly influence the behaviour of liquid droplets: drops impacting solids can “skate on a film of air” [1], so that they can “bounce off walls” [2,3]; reductions in ambient gas pressure can suppress splashing [4] and initiate the merging of colliding droplets [5]; and evaporating droplets can levitate on their own vapour film [7] (the Leidenfrost effect). Despite these advances, the precise physical mechanisms governing these phenomena remains a topic of debate.  A theoretical approach would shed light on these issues, but due to the strongly multiscale nature of these processes brute force computation is infeasible.  Furthermore, when films reach the scale of the mean free path in the gas (i.e. ~100nm) and below, new nanoscale physics appears that renders the classical Navier-Stokes paradigm inaccurate.

In this talk, I will overview our development of efficient computational models for the aforementioned droplet dynamics in the presence of gas nanofilms into which gas-kinetic, van der Waals and/or evaporative effects can be easily incorporated [8,9].  It will be shown that these models can reproduce experimental observations – for example, the threshold between bouncing and wetting for drop impact on a solid is reproduced to within 5%, whilst a model excluding either gas-kinetic or van der Waals effects is ~170% off!  These models will then be exploited to make new experimentally-verifiable predictions, such as how we expect drops to behave in reduced pressure environments.  Finally, I will conclude with some exciting directions for future wor

[1] JM Kolinski et al, Phys. Rev. Lett.  108 (2012), 074503. [2] JM Kolinski et al, EPL.  108 (2014), 24001. [3] J de Ruiter et al, Nature Phys.  11 (2014), 48. [4] L Xu et al, Phys. Rev. Lett. 94 (2005), 184505. [5] J Qian & CK Law, J. Fluid. Mech. 331 (1997), 59.  [6] KL Pan J. Appl. Phys. 103 (2008), 064901. [7] D Quéré, Ann. Rev. Fluid Mech. 45 (2013), 197. [8] JE Sprittles, Phys. Rev. Lett.  118 (2017), 114502.  [9] MV Chubynsky et al, Phys. Rev. Lett.. 124 (2020), 084501.

Capillary forces acting at the surface of a liquid drop can be strong enough to deform small objects and recent studies have provided several examples of elastic instabilities induced by surface tension. Inspired by the windlass mechanism in spider webs, we present a system where a liquid drop sits on a straight fiber and attracts the fiber which thereby coils inside the drop. We then introduce a 2D extension of the mechanism and build a membrane that can extend/contract by a factor of 20.

The key role of physical and mechanical interactions in cancer emerges from a very large variety of data sources and methods - from genomics to bioimaging, from proteomics to clinical records. Thus, learning physics-driven relational information is crucial to characterize its progression at different scales.

In this talk I will discuss how mathematical and computational tools allow for learning  and better understanding of  the mechano-biology of cancer,  thanks to the integration of  patient-specific data and physics-based models. I will present a few applications developed in the last decade in which the development of  digital twins,  empowered by ad-hoc learning tools,  allows us to test new hypotheses,  to assess the model predictions against biological and clinical data, and to aid decision-making in a clinical setting.

Funding from MUR - PRIN 2020, Progetto di Eccellenza 2023-2027 and Regione Lombardia (NEWMED Grant, ID: 117599, POR FESR 2014-2020) is gratefully acknowledged.

We formulate and solve a generalized inverse Navier–Stokes boundary value problem for velocity field reconstruction and simultaneous boundary segmentation of noisy Flow-MRI velocity images. We use a Bayesian framework that combines CFD, Gaussian processes, adjoint methods, and shape optimization in a unified and rigorous manner.
With this framework, we find the velocity field and flow boundaries (i.e. the digital twin) that are most likely to have produced a given noisy image. We also calculate the posterior covariances of the unknown parameters and thereby deduce the uncertainty in the reconstructed flow. First, we verify this method on synthetic noisy images of flows. Then we apply it to experimental phase contrast magnetic resonance (PC-MRI) images of an axisymmetric flow at low and high SNRs. We show that this method successfully reconstructs and segments the low SNR images, producing noiseless velocity fields that match the high SNR images, using 30 times less data.
This framework also provides additional flow information, such as the pressure field and wall shear stress, accurately and with known error bounds. We demonstrate this further on a 3-D in-vitro flow through a 3D-printed aorta and 3-D in-vivo flow through a carotid artery.

To tie in with mental health awareness week, in this session we'll give a brief overview of the mental health support available through the department and university, followed by a panel discussion on how we can look after our mental health as in an academic setting. We're pleased that several of our department Mental Health First Aiders will be panellists - come along for hints and tips on maintaining good mental health and supporting your colleagues and friends.

Join us for our first Fridays@4 session of Trinity about different academic routes people take post-PhD, with a particular focus on fellowships and grants. We’ll hear from Jason Lotay about his experiences on both sides of the application process, as well as hear about the experiences of ECRs in the South Wing, North Wing, and Statistics. Towards the end of the hour we’ll have a Q+A session with the whole panel, where you can ask any questions you have around this topic!