Wed, 10 Nov 2010
10:10
OCCAM Common Room (RI2.28)

Cryoprotectant transport in cartilage

Janet Elliott
(University of Alberta)
Abstract

Cryopreservation (using temperatures down to that of liquid nitrogen at

–196 °C) is the only way to preserve viability and function of mammalian cells for research and transplantation and is integral to the quickly evolving field of regenerative medicine. To cryopreserve tissues, cryoprotective agents (CPAs) must be loaded into the tissue. The loading is critical because of the high concentrations required and the toxicity of the CPAs. Our mathematical model of CPA transport in cartilage describes multi-component, multi-directional, non-dilute transport coupled to mechanics of elastic porous media in a shrinking and swelling domain.

Parameters are obtained by fitting experimental data. We show that predictions agree with independent spatially and temporally resolved MRI experimental measurements. This research has contributed significantly to our interdisciplinary group’s ability to cryopreserve human articular cartilage.

Wed, 03 Nov 2010
10:10
OCCAM Common Room (RI2.28)

Knots and elasticity

Sebastien Neukirch
(Universite Pierre et Marie Curie)
Abstract

We derive solutions of the Kirchhoff equations for a knot tied on an infinitely long elastic rod subjected to combined tension and twist. We consider the case of simple (trefoil) and double (cinquefoil) knots; other knot topologies can be investigated similarly. The rod model is based on Hookean elasticity but is geometrically non-linear. The problem is formulated as a non-linear self-contact problem with unknown contact regions. It is solved by means of matched asymptotic expansions in the limit of a loose knot. Without any a priori assumption, we derive the topology of the contact set, which consists of an interval of contact flanked by two isolated points of contacts. We study the influence of the applied twist on the equilibrium and find an instability for a threshold value of the twist.

Fri, 10 Dec 2010

11:15 - 13:00
OCCAM Common Room (RI2.28)

OCCAM Group Meeting

Various
Abstract
  • Nick Hale - 'Rectangular pseudospectral differentiation matrices' or, 'Why it's not hip to be square'

Boundary conditions in pseudospectral collocation methods are imposed by removing rows of the discretised differential operator and replacing them with others to enforce the required conditions at the boundary. A new approach, based upon projecting the discrete operator onto a lower-degree subspace to create a rectangular matrix and applying the boundary condition rows to ‘square it up’, is described.
We show how this new projection-based method maintains characteristics and advantages of both traditional collocation and tau methods.

  • Cameron Hall - 'Discrete-to-continuum asymptotics of functions defined as sums'

When attempting to homogenise a large number of dislocations, it becomes important to express the stress in a body due to the combined effects of many dislocations. Assuming linear elasticity, this can be written as a simple sum over all the dislocations. In this talk, a method for obtaining an asymptotic approximation to this sum by simple manipulations will be presented. This method can be generalised to approximating one-dimensional functions defined as sums, and work is ongoing to achieve the same results in higher dimensions.

  • Vladimir Zubkov - 'On the tear film modeling'

A great number of works about the tear film behaviour was published. The majority of these works based on modelling with the use of the lubrication approximation. We explore the relevance of the lubrication tear film model compare to the 2D Navier-Stokes model. Our results show that the lubrication model qualitatively describe the tear film evolution everywhere except region close to an eyelid margin. We also present the tear film behaviour using Navier-Stokes model that demonstrates that here is no mixing near the MCJ when the eyelids move relative to the eyeball.

  • Kostas Zygalakis - 'Numerical methods for stiff stochastic differential equations'

Multiscale differential equations arise in the modelling of many important problems in the science and engineering. Numerical methods for such problems have been extensively studied in the deterministic case. In this talk, we will discuss numerical methods for (mean-square stable) stiff stochastic differential equations. In particular we will discuss a generalization of explicit stabilized methods, known as Chebyshev methods to stochastic problems.

Fri, 12 Nov 2010

11:15 - 13:00
OCCAM Common Room (RI2.28)

OCCAM Group Meeting

Various
Abstract
  • Ian Griffiths - "Taylor Dispersion in Colloidal Systems".
  • James Lottes - "Algebraic multigrid for nonsymmetric problems".
  • Derek Moulton - "Surface growth kinematics"
  • Rob Style - "Ice lens formation in freezing soils"
Fri, 08 Oct 2010

11:15 - 13:00
OCCAM Common Room (RI2.28)

OCCAM Group Meeting

Various
Abstract
  • Simon Cotter presents:       “Chemical Fokker-Planck equation and multiscale modelling of (bio)chemical systems”
  • Lian Duan presents:            “History matching problems using Bspline Parameterization”
  • Chris Prior presents:          “Helices, tubes and the Fourier Transform”
Fri, 09 Jul 2010

11:45 - 13:00
OCCAM Common Room (RI2.28)

OCCAM Group Meeting

Various
(OCCAM, University of Oxford)
Abstract

OCCAM Group Meeting 09.07.10

Thu, 08 Jul 2010

10:00 - 11:00
OCCAM Common Room (RI2.28)

Volcanic test of climate mechanisms

Professor Georgiy L. Stenchikov
(KAUST)
Abstract

Strong explosive volcanic eruptions could inject in the lower stratosphere million tons of SO2, which being converted to sulfate aerosols, affect radiative balance of the planet for a few years. During this period the volcanic radiative forcing dominates other forcings producing distinct detectable climate responses. Therefore volcanic impacts provide invaluable natural test of climate nonlinearities and feedback mechanisms. In this talk I will overview volcanic impacts on tropospheric and strsatospheric temperature, ozone, high-latitude circulation, stratosphere-troposphere dynamic interaction, and focus on the long-term volcanic effect on ocean heat content and sea level.

Subscribe to OCCAM Common Room (RI2.28)