15:30
Adapted optimal transport for stochastic processes
Abstract
13:00
Spectrum of 4d near-BPS black holes and their dual CFT
Abstract
While extremal black hole microstates are reproduced by index calculations, the study of near-BPS black holes requires special care to account for quantum fluctuations. A semiclassical analysis indicates that the spectrum of such black holes has a large extremal degeneracy followed by a mass gap up to a continuum of non-BPS states. The inclusion of a theta angle term alters the properties of the spectrum (Witten effect shifting the mass gap and mixed 't Hooft anomaly). This journal club will study two papers by Toldo and Heydeman, [2412.03695] and [2412.03697] where they study 4d near-BPS black holes. As we shall see, a key point of their derivation is the reduction to 2d JT gravity. The dual CFTs are ABJM and some class R (non lagrangian) theories. Since these theories are strongly coupled, the gravity analysis offers a powerful tool to describe their specturm at finite temperature.
15:00
Efficient computation of the persistent homology of Rips complexes
Note: we would recommend to join the meeting using the Teams client for best user experience.
Abstract
Given a point cloud in Euclidean space and a fixed length scale, we can create simplicial complexes (called Rips complexes) to represent that point cloud using the pairwise distances between the points. By tracking how the homology classes evolve as we increase that length scale, we summarise the topology and the geometry of the “shape” of the point cloud in what is called the persistent homology of its Rips filtration. A major obstacle to more widespread take up of persistent homology as a data analysis tool is the long computation time and, more importantly, the large memory requirements needed to store the filtrations of Rips complexes and compute its persistent homology. We bypass these issues by finding a “Reduced Rips Filtration” which has the same degree-1 persistent homology but with dramatically fewer simplices.
The talk is based off joint work is with Musashi Koyama, Facundo Memoli and Vanessa Robins.
INTRODUCTION TO DISCRETE ENERGY ON RECTIFIABLE SETS
Abstract
Discrete and continuous energy problems that arise in a variety of scientific contexts are introduced, along with their fundamental existence and uniqueness results. Particular emphasis will be on Riesz and Gaussian pair potentials and their connections with best-packing and the discretization of manifolds. The latter application leads to the asymptotic theory (as N → ∞) for N-point configurations that minimize energy when the potential is hypersingular (short-range). For fixed N, the determination of such minimizing configurations on the d-dimensional unit sphere S d is especially significant in a range of contexts that include coding theory, discrete geometry, and physics. We will review linear programming methods for proving the optimality of configurations on S d , including Cohn and Kumar’s theory of universal optimality. The following reference will be made available during the short course: Discrete Energy on Rectifiable Sets, by S. Borodachov, D.P. Hardin and E.B. Saff, Springer Monographs in Mathematics, 2019.
Sessions:
Friday, 24 January 14:00-16:00
Friday, 31 January 14:00-16:00
Junior Algebra Social
Abstract
The Junior Algebra and Representation Theory Seminar will kick-off the start of Hilary Term with a social event in the common room. Come to catch up with your fellow students and maybe play a board game or two. Afterwards we'll have lunch together.
Combining computational modelling, deep generative learning and imaging to infer new biology
Abstract
Deep learning algorithms provide unprecedented opportunities to characterise complex structure in large data, but typically in a manner that cannot easily be interpreted beyond the 'black box'. We are developing methods to leverage the benefits of deep generative learning and computational modelling (e.g. fluid dynamics, solid mechanics, biochemistry), particularly in conjunction with biomedical imaging, to enable new insights into disease to be made. In this talk, I will describe our applications in several areas, including modelling drug delivery in cancer and retinal blood vessel loss in diabetes, and how this is leading us into the development of personalised digital twins.
16:00
Continuity of heights and complete intersections in toric varieties
Abstract
I will describe the contents of a joint project with Pablo Destic and Nuno Hultberg. In the paper we confirm a conjecture of Roberto Gualdi regarding a formula for the average height of the intersection of twisted (by roots of unity) hyperplanes in a toric variety. I will introduce the 'GVF analytification' of a variety, which is defined similarly as the Berkovich analytification, but with norms replaced by heights. Moreover, I will discuss some motivations coming from (continuous) model theory and Arakelov geometry.
Multi-Index Monte Carlo Method for Semilinear Stochastic Partial Differential Equations
Abstract
We present an exponential-integrator-based multi-index Monte Carlo (MIMC) method for the weak approximation of mild solutions to semilinear stochastic partial differential equations (SPDEs). Theoretical results on multi-index coupled solutions of the SPDE are provided, demonstrating their stability and the satisfaction of multiplicative error estimates. Leveraging this theory, we develop a tractable MIMC algorithm. Numerical experiments illustrate that MIMC outperforms alternative approaches, such as multilevel Monte Carlo, particularly in low-regularity settings.
13:00
Aspects of anomalies - Part 2
Abstract
Anomalies in quantum systems are present when a classical symmetry is broken by quantum effects. They give rise to physical predictions and constraints. This talk will focus on the mathematical features of anomalies of continuous, ordinary, symmetries. In the first part, we will review the topological nature of anomalies, in particular the connection to the Atiyah-Singer index theorem and its non-perturbative path-integral computation by Fujikawa. We will then discuss how anomalies and their associated (topological) Chern-Simons polynomials are related to BRST cohomology via the Stora-Zumino chain of descent equations, explaining the connection to the two-step descent procedure reviewed in the talk by Alice Lüscher last term.
Junior Strings is a seminar series where DPhil students present topics of common interest that do not necessarily overlap with their own research area. This is primarily aimed at PhD students and post-docs but everyone is welcome.
Optimal design of odd active solids
Abstract
Active solids consume energy to allow for actuation and shape change not possible in equilibrium. I will first introduce active solids in comparison with their active fluid counterparts. I will then focus on active solids composed of non-reciprocal springs and show how so-called odd elastic moduli arise in these materials. Odd active solids have counter-intuitive elastic properties and require new design principles for optimal response. For example, in floppy lattices, zero modes couple to microscopic non-reciprocity, which destroys odd moduli entirely in a phenomenon reminiscent of rigidity percolation. Instead, an optimal odd lattice will be sufficiently soft to activate elastic deformations, but not too soft. These results provide a theoretical underpinning for recent experiments and point to the design of novel soft machines.
Anton Souslov is an Associate Professor of Theoretical Statistical Physics working on the theory of soft materials, including mechanical metamaterials, active matter, topological states, and polymer physics.
Efficient Adaptive Regularized Tensor Methods
Abstract
High-order tensor methods employing local Taylor approximations have attracted considerable attention for convex and nonconvex optimisation. The pth-order adaptive regularisation (ARp) approach builds a local model comprising a pth-order Taylor expansion and a (p+1)th-order regularisation term, delivering optimal worst-case global and local convergence rates. However, for p≥2, subproblem minimisation can yield multiple local minima, and while a global minimiser is recommended for p=2, effectively identifying a suitable local minimum for p≥3 remains elusive.
This work extends interpolation-based updating strategies, originally proposed for p=2, to cases where p≥3, allowing the regularisation parameter to adapt in response to interpolation models. Additionally, it introduces a new prerejection mechanism to discard unfavourable subproblem minimisers before function evaluations, thus reducing computational costs for p≥3.
Numerical experiments, particularly on Chebyshev-Rosenbrock problems with p=3, indicate that the proper use of different minimisers can significantly improve practical performance, offering a promising direction for designing more efficient high-order methods.
A new axiom for Q_p^ab and non-standard methods for perfectoid fields
Abstract
The class of henselian valued fields with non-discrete value group is not well-understood. In 2018, Koenigsmann conjectured that a list of seven natural axioms describes a complete axiomatisation of Q_p^ab, the maximal extension of the p-adic numbers Q_p with abelian Galois group, which is an example of such a valued field. Informed by the recent work of Jahnke-Kartas on the model theory of perfectoid fields, we formulate an eighth axiom (the discriminant property) that is not a consequence of the other seven. Revisiting work by Koenigsmann (the Galois characterisation of Q_p) and Jahnke-Kartas, we give a uniform treatment of their underlying method. In particular, we highlight how this method yields short, non-standard model-theoretic proofs of known results (e.g. finite extensions of perfectoid fields are perfectoid).
16:00
Skein Lasagna Modules
Abstract
Donaldson proved that there are pairs of 4-manifolds that are homeomorphic but not diffeomorphic, a phenomenon that does not appear for any lower dimensional manifolds. Until recently, proving this for compact manifolds has required smooth 4-manifold invariants coming from gauge theory. In this talk, we will give an introduction to an exciting new smooth 4-manifold invariant of Morrison Walker and Wedich, called a skein lasagna module that does not rely on gauge theory. Further, this talk will not assume any knowledge of 4-manifold topology.
11:00
Adapted Wasserstein distance between continuous Gaussian processes
Abstract
Quo Vadis
Abstract
Paraphrasing the title of Riemann’s famous lecture of 1854 I ask: What is the most rudimentary notion of a geometry? A possible answer is a path system: Consider a finite set of “points” $x_1,…,x_n$ and provide a recipe how to walk between $x_i$ and $x_j$ for all $i\neq j$, namely decide on a path $P_{ij}$, i.e., a sequence of points that starts at $x_i$ and ends at $x_j$, where $P_{ji}$ is $P_{ij}$, in reverse order. The main property that we consider is consistency. A path system is called consistent if it is closed under taking subpaths. What do such systems look like? How to generate all of them? We still do not know. One way to generate a consistent path system is to associate a positive number $w_{ij}>0$ with every pair and let $P_{ij}$ be the corresponding $w$-shortest path between $x_i$ and $x_j$. Such a path system is called metrical. It turns out that the class of consistent path systems is way richer than the metrical ones.
My main emphasis in this lecture is on what we don’t know and wish to know, yet there is already a considerable body of work that we have done on the subject.
The new results that I will present are joint with my student Daniel Cizma as well as with him and with Maria Chudnovsky.
16:00
Typical hyperbolic surfaces have an optimal spectral gap
Abstract
16:00
Quantum symmetries on Kirchberg algebras
Abstract
In subfactor theory, it has been observed that operator algebras often admit symmetries beyond mere groups, sometimes called quantum symmetries. Besides recent substantial progress on the classification programs of simple amenable C*-algebras and group actions on them, there has been increasing interest in their quantum symmetries. This talk is devoted to an attempt to ensure the existence of various quantum symmetries on simple amenable C*-algebras, at least in the purely infinite case, by providing a systematic way to produce them. As a technical ingredient, a simplicity criterion for certain Pimsner algebras is given.
15:30
Deformations and lifts of Calabi-Yau varieties in characteristic p
Abstract
Derived algebraic geometry allows us to study formal moduli problems via their tangent Lie algebras. After briefly reviewing this general paradigm, I will explain how it sheds light on deformations of Calabi-Yau varieties.
In joint work with Taelman, we prove a mixed characteristic analogue of the Bogomolov–Tian–Todorov theorem, which asserts that Calabi-Yau varieties in characteristic $0$ are unobstructed. Moreover, we show that ordinary Calabi–Yau varieties in characteristic $p$ admit canonical (and algebraisable) lifts to characteristic $0$, generalising results of Serre-Tate for abelian varieties and Deligne-Nygaard for K3 surfaces.
If time permits, I will conclude by discussing some intriguing questions related to our canonical lifts.
15:00
Counting non-simple closed geodesics on random hyperbolic surfaces
Abstract
On inapproximability of hypergraph colourings and beyond
Abstract
I'll discuss how a certain notion of symmetry captures the computational complexity of approximating homomorphism problems between relational structures, also known as constraint satisfaction problems. I'll present recent results on inapproximability of conflict-free and linearly-ordered hypergraph colourings and solvability of systems of equations.
Proof of the Deligne—Milnor conjecture
Abstract
Let X --> S be a family of algebraic varieties parametrized by an infinitesimal disk S, possibly of mixed characteristic. The Bloch conductor conjecture expresses the difference of the Euler characteristics of the special and generic fibers in algebraic and arithmetic terms. I'll describe a proof of some new cases of this conjecture, including the case of isolated singularities. The latter was a conjecture of Deligne generalizing Milnor's formula on vanishing cycles.
This is joint work with Massimo Pippi; our methods use derived and non-commutative algebraic geometry.
13:00
Celestial Holography and Self-Dual Einstein Gravity
Abstract
Celestial Holography posits the existence of a holographic description of gravitational theories in asymptotically flat space-times. To date, top-down constructions of such dualities involve a combination of twisted holography and twistor theory. The gravitational theory is the closed string B model living in a suitable twistor space, while the dual is a chiral 2d gauge theory living on a stack of D1 branes wrapping a twistor line. I’ll talk about a variant of these models that yields a theory of self-dual Einstein gravity (via the Plebanski equations) in four dimensions. This is based on work in progress with Roland Bittleston, Kevin Costello & Atul Sharma.
16:30
Fluctuations around the mean-field limit for attractive Riesz interaction kernels in the moderate regime
Abstract
In this talk I will give a short introduction to moderately interacting particle systems and the general notion of fluctuations around the mean-field limit. We will see how a central limit theorem can be shown for moderately interacting particles on the whole space for certain types of interaction potentials. The interaction potential approximates singular attractive potentials of sub-Coulomb type and we can show that the fluctuations become asymptotically Gaussians. The methodology is inspired by the classical work of Oelschläger in the 1980s on fluctuations for the porous-medium equation. To allow for attractive potentials we use a new approach of quantitative mean-field convergence in probability in order to include aggregation effects.
15:30
The Farrell--Jones Conjecture and automorphisms of relatively hyperbolic groups
Abstract
The Farrell--Jones conjecture predicts that the algebraic K-theory of a group ring is isomorphic to a certain equivariant homology theory, and there are also versions for L-theory and Waldhausen's A-theory. In principle, this provides a way to calculate these K-groups, and has many applications. These include classifying manifolds admitting a given fundamental group and a positive resolution of the Borel conjecture.
I will discuss work with Yassine Guerch and Sam Hughes on the Farrell--Jones conjecture for extensions of relatively hyperbolic groups, as well as an application to their automorphism groups in the one-ended case. The methods are from geometric group theory: we go via the theory of JSJ decompositions to produce acylindrical actions on trees.
15:30
Heat kernel for critical percolation clusters on the binary tree.
Abstract
14:15
Yang-Mills on an ALF-fibration
Abstract
In this talk, we will make an explicit link between self-dual Yang-Mills instantons on the Taub-NUT space, and G2-instantons on the BGGG space, by displaying the latter space as a fibration by the former. In doing so, we will discuss analysis on non-compact manifolds, circle symmetries, and a new method of constructing solutions to quadratically singular ODE systems. This talk is based on joint work with Matt Turner: https://arxiv.org/pdf/2409.03886.
Symmetry Enhancement, SPT Absorption, and Duality in QED_3
Abstract
Abelian gauge theories in 2+1 dimensions are very interesting QFTs: they are strongly coupled and exhibit non-trivial dynamics. However, they are somewhat more tractable than non-Abelian theories in 3+1 dimensions. In this talk, I will first review the known properties of fermions in 2+1 dimensions and some conjectures about QED_3 with a single Dirac fermion. I will then present the recent proposal from [arXiv:2409.17913] regarding the phase diagram of QED_3 with two fermions. The findings reveal surprising (yet compelling) features: while semiclassical analysis would suggest two trivially gapped phases and a single phase transition, the actual dynamics indicate the presence of two distinct phase transitions separated by a "quantum phase." This intermediate phase exists over a finite range of parameters in the strong coupling regime and is not visible semiclassically. Moreover, these phase transitions are second-order and exhibit symmetry enhancement. The proposal is supported by several non-trivial checks and is consistent with results from numerical bootstrap, lattice simulations, and extrapolations from the large-Nf expansion.
Do individuals matter? - From psychology, via wound healing and calcium signalling to ecology
Abstract
16:00
Geodesic cycles and Eisenstein classes for SL(2,Z)
Abstract
The geodesic cycles (resp. Eisenstein classes) for SL(2,Z) are special classes in the homology (resp. cohomology) of modular curve (for SL(2,Z)) defined by the closed geodesics (resp. Eisenstein series). It is known that the pairing between these geodesic cycles and Eisenstein classes gives the special values of partial zeta functions of real quadratic fields, and this has many applications. In this talk, I would like to report on some recent observations on the size of the homology subgroup generated by geodesic cycles and their applications. This is a joint work with Ryotaro Sakamoto.
12:00
Asymptotic Higher Spin Symmetries in Gravity.
Abstract
I will first give a short review of the concepts of Asymptotically Flat Spacetimes, IR triangle and Noether's theorems. I will then present what Asymptotic Higher Spin Symmetries are and how they were introduced as a candidate for an approximate symmetry of General Relativity and the S-matrix. Next, I'll move on to the recent developments of establishing these symmetries as Noether symmetries and describing how they are canonically and non-linearly realized on the asymptotic gravitational phase space. I will discuss how the introduction of dual equations of motion encapsulates the non-perturbativity of the analysis. Finally I'll emphasize the relation to twistor, especially with 2407.04028. Based on 2409.12178 and 2410.15219
14:00
A Subspace-conjugate Gradient Method for Linear Matrix Equations
Abstract
15:30
Unstable cohomology of SL(n,Z) and Hopf algebras
Abstract
I want to give a survey about the rational cohomology of SL_n
Z. This includes recent developments of finding Hopf algebras in the
direct sum of all cohomology groups of SL_n Z for all n. I will give a
quick overview about Hopf algebras and what this structure implies for
the cohomology of SL_n Z.
16:00
Fridays@4 – A start-up company? 10 things I wish I had known
Abstract
Are you thinking of launching your own start-up or considering joining an early-stage company? Navigating the entrepreneurial landscape can be both exciting and challenging. Join Pete for an interactive exploration of the unwritten rules and hidden insights that can make or break a start-up journey.
Drawing from personal experience, Pete's talk will offer practical wisdom for aspiring founders and team members, revealing the challenges and opportunities of building a new business from the ground up.
Whether you're an aspiring entrepreneur, a potential start-up team member, or simply curious about innovative businesses, you'll gain valuable perspectives on the realities of creating something from scratch.
This isn't a traditional lecture – it will be a lively conversation that invites participants to learn, share, and reflect on the world of start-ups. Come prepared to challenge your assumptions and discover practical insights that aren't found in standard business guides.

Speaker: Professor Pete Grindrod
15:00
From single neurons to complex human networks using algebraic topology
Note: we would recommend to join the meeting using the Teams client for best user experience.
Abstract
Topological data analysis, and in particular persistent homology, has provided robust results for numerous applications, such as protein structure, cancer detection, and material science. In the field of neuroscience, the applications of TDA are abundant, ranging from the analysis of single cells to the analysis of neuronal networks. The topological representation of branching trees has been successfully used for a variety of classification and clustering problems of neurons and microglia, demonstrating a successful path of applications that go from the space of trees to the space of barcodes. In this talk, I will present some recent results on topological representation of brain cells, with a focus on neurons. I will also describe our solution for solving the inverse TDA problem on neurons: how can we efficiently go from persistence barcodes back to the space of neuronal trees and what can we learn in the process about these spaces. Finally, I will demonstrate how algebraic topology can be used to understand the links between single neurons and networks and start understanding the brain differences between species. The organizational principles that distinguish the human brain from other species have been a long-standing enigma in neuroscience. Human pyramidal cells form highly complex networks, demonstrated by the increased number and simplex dimension compared to mice. This is unexpected because human pyramidal cells are much sparser in the cortex. The number and size of neurons fail to account for this increased network complexity, suggesting that another morphological property is a key determinant of network connectivity. By comparing the topology of dendrites, I will show that human pyramidal cells have much higher perisomatic (basal and oblique) branching density. Therefore greater dendritic complexity, a defining attribute of human L2 and 3 neurons, may provide the human cortex with enhanced computational capacity and cognitive flexibility.
End-of-term mathematical board games
Abstract
Would you like to meet some of your fellow students, and some graduate students and postdocs, in an informal and relaxed atmosphere, while building your communication skills? In this Friday@2 session, you'll be able to play a selection of board games, meet new people, and practise working together. What better way to spend the final Friday afternoon of term?! We'll play the games in the south Mezzanine area of the Andrew Wiles Building.
Some Uniserial Specht Modules
Abstract
12:00
Combinatorial proof of a Non-Renormalization theorem
Abstract
In "Higher Operations in Perturbation Theory", Gaiotto, Kulp, and Wu discussed Feynman integrals that control certain deformations in quantum field theory. The corresponding integrands are differential forms in Schwinger parameters. Specifically, the integrand $\alpha$ is associated to a single topological direction of the theory.
I will show how the combinatorial properties of graph polynomials lead to a relatively simple, explicit formula for $\alpha$, that can be evaluated quickly with a computer. This is interesting for two reasons. Firstly, knowing the explicit formula leads to an elementary proof of the fact that $\alpha$ squares to zero, which asserts the absence of quantum corrections in topological field theories of two (or more) dimensions, known as Kontsevich's formality theorem. Secondly, the underlying constructions and proofs are not intrinsically limited to topological theories. In this sense, they serve as a particularly instructive example for simplifications that can occur in Feynman integrals with numerators.
Spatial mechano-transcriptomics of mouse embryogenesis
Abstract
Advances in spatial profiling technologies are providing insights into how molecular programs are influenced by local signalling and environmental cues. However, cell fate specification and tissue patterning involve the interplay of biochemical and mechanical feedback. Here, we propose a new computational framework that enables the joint statistical analysis of transcriptional and mechanical signals in the context of spatial transcriptomics. To illustrate the application and utility of the approach, we use spatial transcriptomics data from the developing mouse embryo to infer the forces acting on individual cells, and use these results to identify mechanical, morphometric, and gene expression signatures that are predictive of tissue compartment boundaries. In addition, we use geoadditive structural equation modelling to identify gene modules that predict the mechanical behaviour of cells in an unbiased manner. This computational framework is easily generalized to other spatial profiling contexts, providing a generic scheme for exploring the interplay of biomolecular and mechanical cues in tissues.
17:00
Model-theoretic havens for extremal and additive combinatorics
Abstract
Model-theoretic dividing lines have long been a source of tameness for various areas of mathematics, with combinatorics jumping on the bandwagon over the last decade or so. Szemerédi’s regularity lemma saw improvements in the realm of NIP, which were further refined in the subrealms of stability and distality. We show how relations satisfying the distal regularity lemma enjoy improved bounds for Zarankiewicz’s problem. We then pivot to arithmetic regularity lemmas as pioneered by Green, for which NIP and stability also imply improvements. Unsettled by the absence of distality in this picture, we discuss the role of distality in additive combinatorics, appealing to our result connecting distality with arithmetic tameness.
Transportation market rate forecast using signature transform
Abstract
Freight transportation marketplace rates are typically challenging to forecast accurately. In this talk, I will present a novel statistical technique based on signature transforms and a predictive and adaptive model to forecast these marketplace rates. Our technique is based on two key elements of the signature transform: one being its universal nonlinearity property, which linearizes the feature space and hence translates the forecasting problem into linear regression, and the other being the signature kernel, which allows for comparing computationally efficiently similarities between time series data. Combined, it allows for efficient feature generation and precise identification of seasonality and regime switching in the forecasting process.
An algorithm based on our technique has been deployed by Amazon trucking operations, with far superior forecast accuracy and better interpretability versus commercially available industry models, even during the COVID-19 pandemic and the Ukraine conflict. Furthermore, our technique is in production in Amazon and has been adopted for Amazon finance planning, with an estimated annualized saving of $50MM in the transportation sector alone.
16:00
Mean Field Games in a Stackelberg problem with an informed major player
Abstract
We investigate a stochastic differential game in which a major player has a private information (the knowledge of a random variable), which she discloses through her control to a population of small players playing in a Nash Mean Field Game equilibrium. The major player’s cost depends on the distribution of the population, while the cost of the population depends on the random variable known by the major player. We show that the game has a relaxed solution and that the optimal control of the major player is approximatively optimal in games with a large but finite number of small players. Joint work with Pierre Cardaliaguet and Catherine Rainer.
Please join us for refreshments outside the lecture room from 15:30.
16:00
Zeros of polynomials with restricted coefficients: a problem of Littlewood
Abstract
The study of polynomials whose coefficients lie in a given set $S$ (the most notable examples being $S=\{0,1\}$ or $\{-1,1\}$) has a long history leading to many interesting results and open problems. We begin with a brief general overview of this topic and then focus on the following old problem of Littlewood. Let $A$ be a set of positive integers, let $f_A(x)=\sum_{n\in A}\cos(nx)$ and define $Z(f_A)$ to be the number of zeros of $f_A$ in $[0,2\pi]$. The problem is to estimate the quantity $Z(N)$ which is defined to be the minimum of $Z(f_A)$ over all sets $A$ of size $N$. We discuss recent progress showing that $Z(N)\geqslant (\log \log N)^{1-o(1)}$ which provides an exponential improvement over the previous lower bound.
A closely related question due to Borwein, Erd\'elyi and Littmann asks about the minimum number of zeros of a cosine polynomial with $\pm 1$-coefficients. Until recently it was unknown whether this even tends to infinity with the degree $N$. We also discuss work confirming this conjecture.
The Art of Cancer Modelling
Abstract
In this talk we will provide an overview of a number of mathematical models of cancer growth and development - gene regulatory networks, the immune response to cancer, avascular solid tumour growth, tumour-induced angiogenesis, cancer invasion and metastasis. In the talk we will also discuss (the art of) mathematical modelling itself giving illustrations and analogies from works of art.
Mark Chaplain is the Gregory Chair of Applied Mathematics at the University of St. Andrews.
Here's a little about his research from the St. Andrews website:
Research areas
Cancer is one of the major causes of death in the world, particularly the developed world, with around 11 million people diagnosed and around 9 million people dying each year. The World Health Organisation (WHO) predicts that current trends show the number rising to 11.5 million in 2030. There are few individuals who have not been touched either directly or indirectly by cancer. While treatment for cancer is continually improving, alternative approaches can offer even greater insight into the complexity of the disease and its treatment. Biomedical scientists and clinicians are recognising the need to integrate data across a range of spatial and temporal scales (from genes through cells to tissues) in order to fully understand cancer.
My main area of research is in what may be called "mathematical oncology" i.e. formulating and analysing mathematical models of cancer growth and treatment. I have been involved in developing a variety of novel mathematical models for all the main phases of solid tumour growth, namely: avascular solid tumour growth, the immune response to cancer, tumour-induced angiogenesis, vascular tumour growth, invasion and metastasis.
The main modelling techniques involved are the use and analysis of nonlinear partial and ordinary differential equations, the use of hybrid continuum-discrete models and the development of multiscale models and techniques.
Much of my current work is focussed on what may be described as a "systems approach" to modelling cancer growth through the development of quantitative and predictive mathematical models. Over the past 5 years or so, I have also helped develop models of chemotherapy treatment of cancer, focussing on cell-cycle dependent drugs, and also radiotherapy treatment. One of the new areas of research I have started recently is in modelling intracellular signalling pathways (gene regulation networks) using partial differential equation models.
The long-term goal is to build a "virtual cancer" made up of different but connected mathematical models at the different biological scales (from genes to tissue to organ). The development of quantitative, predictive models (based on sound biological evidence and underpinned and parameterised by biological data) has the potential to have a positive impact on patients suffering from diseases such as cancer through improved clinical treatment.
Further details of my current research can be found at the Mathematical Biology Research Group web page.
16:00
C*-diagonals in the C*-algebras of non-principal twisted groupoids
Abstract
The reduced twisted C*-algebra A of an étale groupoid G has a canonical abelian subalgebra D: functions on G's unit space. When G has no non-trivial abelian subgroupoids (i.e., G is principal), then D is in fact maximal abelian. Remarkable work by Kumjian shows that the tuple (A,D) allows us to reconstruct the underlying groupoid G and its twist uniquely; this uses that D is not only masa but even what is called a C*-diagonal. In this talk, I show that twisted C*-algebras of non-principal groupoids can also have such C*-diagonal subalgebras, arising from non-trivial abelian subgroupoids, and I will discuss the reconstructed principal twisted groupoid of Kumjian for such pairs of algebras.
Solving (algebraic problems from) PDEs; a personal perspective
Abstract
We are now able to solve many partial differential equation problems that were well beyond reach when I started in academia. Some of this success is due to computer hardware but much is due to algorithmic advances.
I will give a personal perspective of the development of computational methodology in this area over my career thus far.
13:00
Resurgence
Abstract
Perturbation theory is one of the main tools in the modern physicist's toolbox to solve problems. Indeed, it can often the only approach we have to computing any quantity of interest in a physical theory. However, perturbative contributions can actually grow as we increase the order. Thus, many perturbative series in physics are asymptotic, with 0 radius of convergence. In this talk, I will describe resurgence, which gives us a way of treat such series, by adding non-perturbative effects in a systematic manner.
Junior Strings is a seminar series where DPhil students present topics of common interest that do not necessarily overlap with their own research area. This is primarily aimed at PhD students and post-docs but everyone is welcome.
Who needs a residual when an approximation will do?
Abstract
The widespread need to solve large-scale linear systems has sparked a growing interest in randomized techniques. One such class of techniques is known as iterative random sketching methods (e.g., Randomized Block Kaczmarz and Randomized Block Coordinate Descent). These methods "sketch" the linear system to generate iterative, easy-to-compute updates to a solution. By working with sketches, these methods can often enable more efficient memory operations, potentially leading to faster performance for large-scale problems. Unfortunately, tracking the progress of these methods still requires computing the full residual of the linear system, an operation that undermines the benefits of the solvers. In practice, this cost is mitigated by occasionally computing the full residual, typically after an epoch. However, this approach sacrifices real-time progress tracking, resulting in wasted computations. In this talk, we use statistical techniques to develop a progress estimation procedure that provides inexpensive, accurate real-time progress estimates at the cost of a small amount of uncertainty that we effectively control.
Chaotic flows in polymer solutions: what’s new?
Abstract
It is well known that adding even small amounts of long chain polymers (e.g. few parts per million) to Newtonian solvents can drastically change the flow behaviour by introducing elasticity. In particular, two decades ago, experiments in curved geometries demonstrated that polymer flows can be chaotic even at vanishingly small Reynolds numbers. The situation in `straight’ flows such as pressure-driven flow down a channel is less clear and hence an area of current focus. I will discuss recent progress.
Rich Kerswell is a professor in the Department of Applied Mathematics and Theoretical Physics (DAMTP) at the University of Cambridge. His research focuses on fluid dynamics, particularly in the transition to turbulence, geophysical fluid flows, and nonlinear dynamics. Kerswell is known for studying how simple fluid systems can exhibit complex, chaotic behavior and has contributed to understanding turbulence's onset and sustainment in various contexts, including pipes and planetary atmospheres. His work integrates mathematical modeling, theoretical analysis, and computational simulations to explore instabilities and the fundamental mechanisms governing fluid behavior in nature and industry.