Modelling Magnetically Targeted Stem Cell Delivery

The development of an effective method of targeting delivery of stem cells to the site of an injury is a key challenge in regenerative medicine. However, production of stem cells is costly and current delivery methods rely on large doses in order to be effective. Improved targeting through use of an external magnetic field to direct delivery of magnetically-tagged stem cells to the injury site would allow for smaller doses to be used.
We present a model for delivery of stem cells implanted with a fixed number of magnetic nanoparticles under the action of an external magnetic field. We examine the effect of magnet geometry and strength on therapy efficacy. The accuracy of the mathematical model is then verified against experimental data provided by our collaborators at the University of Birmingham.