How can a random walker on a network be helpful for patients suffering from amyotrophic lateral sclerosis (ALS)? Clinical trials in ALS continue to rely on survival or clinical functional scales as endpoints, since anatomical patterns of disease spread in ALS are poorly characterized in vivo. In this study, we generated individual brain networks of patients and controls based on cerebral magnetic resonance imaging (MRI) data. Then, we applied a computational model with a random walker to the brain MRI scan of patients to simulate this progressive network degeneration. We observe that computer‐simulated aggregation levels of the random walker mimic true disease patterns in ALS patients. Our results demonstrate the utility of computational network models in ALS to predict disease progression and underscore their potential as a prognostic biomarker.
After presenting this study on characterizing the structural changes in neurodegenerative diseases with network science, I will give an outlook on my new work on characterizing the dynamic changes in brain networks for Parkinson’s disease and counteracting these with (simulated) deep brain stimulation using the neuroinformatics platform The Virtual Brain (www.thevirtualbrain.org) .
Article link: https://onlinelibrary.wiley.com/doi/full/10.1002/ana.25706