I will present classification results for 4-manifolds with boundary and infinite cyclic fundamental group, obtained in joint work with Anthony Conway and with Conway and Lisa Piccirillo. Time permitting, I will describe applications to knotted surfaces in simply connected 4-manifolds, and to investigating the difference between the relations of homotopy equivalence and stable homeomorphism. These will also draw on work with Patrick Orson and with Conway, Diarmuid Crowley, and Joerg Sixt.