The S-Matrix in flat space is a naturally holographic observable. S-Matrix elements thus contain valuable information about the putative dual CFT. In this talk, I will first introduce some basic aspects of Celestial Holography and then explain how these can be inferred directly from scattering amplitudes. I will then focus on how the singularity structure of amplitudes interplays with traditional CFT structures particularly in the context of the operator product expansion (OPE) of the dual CFT. I will conclude with some discussion about the role played by supersymmetry in simplifying the putative dual CFT.