Physical Network Constraints Define the Lognormal Architecture of the Brain's Connectome

While the brain has long been conceptualized as a network of neurons connected by synapses, attempts to describe the connectome using established models in network science have yielded conflicting outcomes, leaving the architecture of neural networks unresolved. Here, we analyze eight experimentally mapped connectomes, finding that the degree and the strength distribution of the underlying networks cannot be described by random nor scale-free models. Rather, the node degrees and strengths are well approximated by lognormal distributions, whose emergence lacks a mechanistic model in the context of networks. Acknowledging the fact that the brain is a physical network, whose architecture is driven by the spatially extended nature of its neurons, we analytically derive the multiplicative process responsible for the lognormal neuron length distribution, arriving to a series of empirically falsifiable predictions and testable relationships that govern the degree and the strength of individual neurons. The lognormal network characterizing the connectome represents a novel architecture for network science, that bridges critical gaps between neural structure and function, with unique implications for brain dynamics, robustness, and synchronization.