13:00
In this Fridays@4 event – for this week renamed Fridays@1 (with lunchtime pizza) – Torkel Loman from the Mathematics Institute and Alastair McCullough from the Department of Computer Science will present their talks.
Torkel Loman
The behaviours of noisy feedback loops and where (in parameter space) to find them
Alastair McCullough
Tech, Coffee, and the Regulation of Truth: An Enterprise Barista's Story
Torkel's abstract
Mixed positive/negative feedback loops (networks where a single component both activates and deactivates its own productions) are common across biological systems, and also the subject of this talk. Here (inspired by systems for e.g. bacterial antibiotics resistance), we create a minimal mathematical model of such a feedback loop. Our model (a stochastic delay differential equation) depends on only 6, biologically interpretable, parameters. We describe 10 distinct behaviours that such feedback loops can produce, and map their occurrence across 6-dimensional parameter space.
