Transmural propagation of the action potential in mammalian hearts: marrying experimental and theoretical studies
Abstract
Transmural propagation is a little studied feature of mammalian electrophysiology, this talk reviews our experimental work using different optical techniques to characterise this mode
of conduction under physiological and pathophysiological conditions.
What can we reconstruct about neural organization from time series of electrophysiological recordings?
Abstract
We will discuss how the analysis of a stochastic mean-field model for
synaptic activity can be used to reconstruct some parameters about
neuronal networks. The method is based on a non-standard analysis of the
Fokker-Planck equation and the asymptotic computation of the spectrum for
the nonself-adjoint operator. Applications concern Up- and Down- states
and bursting activity in neuronal networks.
oxDNA: A coarse-grained approach to model DNA
Abstract
Simulating the long time and length scales associated with DNA self-assembly
and DNA nanotechnology is not currently feasible with models at an atomic level
of detail. We, therefore, developed oxDNA a coarse-grained representation of
DNA that aims to capture the fundamental structural, thermodynamic and
mechanical properties of double-stranded and single-stranded DNA, which we have
subsequently applied to study a wide variety of DNA biophysical properties and
DNA nanotechnological systems.