Classical work of Jeffery from 1922 established how at low Reynolds number, ellipsoids in steady shear flow undergo periodic motion with non-uniform rotation rate, termed 'Jeffery orbits'.  I will present two problems where Jeffery orbits play a critical role in understanding the transport and aggregation of rod-shaped organisms.  I will discuss the trapping of motile chemotactic bacteria in high shear, and the sedimentation rate of negatively buoyant plankton. 

In the first part of this talk the two-dimensional Landau-de Gennes energy with several elastic constants, subject to general k-radial symmetric boundary conditions, will be analysed. It will be shown that for generic elastic constants the critical points consistent with the symmetry of the boundary conditions exist only in the case k=2. Analysis of the associated harmonic map type problem arising in the limit of small elastic constants allows to identify three types of radial profiles: with two, three or full five components. In the second part of the talk different paths for emergency of non-radially symmetric solutions and their analytical structure in 2D as well as 3D cases will be discussed. These results is a joint work with Jonathan Robbins, Valery Slastikov and Arghir Zarnescu.
 

It is a classical theorem of Magnus that the word problem for one-relator groups is solvable; its precise complexity remains unknown. A geometric characterization of the complexity is given by the Dehn function. I will present joint work with Daniel Woodhouse showing that one-relator groups have a rich collection of Dehn functions, including the Brady--Bridson snowflake groups on which our work relies.
 

Given an endomorphism f:X --> X of a 'dualisable' object in a symmetric monoidal category, one can define its trace Tr(f). It turns out that the trace is 'universal' among the scalars we can produce from f. To prove this we will think of the 1d framed bordism category as the 'walking dualisable object' (using the cobordism hypothesis) and then apply the Yoneda lemma.
Employing similar techniques we can define 'hermitian' objects (generalising hermitian vector spaces) and prove that there is a 1-1 correspondence between Hermitian structures on a fixed object X and self-adjoint automorphisms of X. If time permits I will sketch how this relates to hermitian K-theory.

While all results of the talk hold for infinity-categories, they work equally well for ordinary categories. Therefore no knowledge of higher category theory is needed to follow the talk.

Collective neural crest (NC) cell migration determines the formation of peripheral tissues during vertebrate development. If NC cells fail to reach a target or populate an incorrect location, improper cell differentiation or uncontrolled cell proliferation can occur. Therefore, knowledge of embryonic cell migration is important for understanding birth defects and tumour formation. However, the response of NC cells to different stimuli, and their ability to migrate to distant targets, are still poorly understood. Recently, experimental and computational studies have provided evidence that there are at least two subpopulations of NC cells, namely “leading” and “trailing” cells, with potential further differentiation between the cells in these subpopulations [1,2]. The main difference between these two cell types is the mechanism driving motility and invasion: the leaders follow the gradient of a chemoattractant, while the trailing cells follow “gradients” of the leaders. The precise mechanisms underlying these leader-follower interactions are still unclear.

We develop and apply innovative multi-scale modelling frameworks to analyse signalling effects on NC cell dynamics. We consider different potential scenarios and investigate them using an individual-based model for the cell motility and reaction-diffusion model to describe chemoattractant dynamics. More specifically, we use a discrete self-propelled particle model [3] to capture the interactions between the cells and incorporate volume exclusion. Streaming migration is represented using an off-lattice model to generate realistic cell arrangements and incorporate nonlinear behaviour of the system, for example the coattraction between cells at various distances. The simulations are performed using Aboria, which is a C++ library for the implementation of particle-based numerical methods [4]. The source of chemoattractant, the characteristics of domain growth, and types of boundary conditions are some other important factors that affect migration. We present results on how robust/sensitive cells invasion is to these key biological processes and suggest further avenues of experimental research.

[1] R. McLennan, L. Dyson, K. W. Prather, J. A. Morrison, R.E. Baker, P. K. Maini and P. M. Kulesa. (2012). Multiscale mechanisms of cell migration during development: theory and experiment, Development, 139, 2935-2944.

[2] R. McLennan, L. J. Schumacher, J. A. Morrison, J. M. Teddy, D. A. Ridenour, A. C. Box, C. L. Semerad, H. Li, W. McDowell, D. Kay, P. K. Maini, R. E. Baker and P. M. Kulesa. (2015). Neural crest migration is driven by a few trailblazer cells with a unique molecular signature narrowly confined to the invasive front, Development, 142, 2014-2025.

[3] G. Grégoire, H. Chaté and Y Tu. (2003). Moving and staying together without a leader, Physica D: Nonlinear Phenomena, 181, 157-170.

[4] M. Robinson and M. Bruna. (2017). Particle-based and meshless methods with Aboria, SoftwareX, 6, 172-178. Online documentation https://github.com/martinjrobins/Aboria.

The Simonyi Lecture is an annual lecture under the auspices of the Charles Simonyi Professor for the Public Understanding of Science, Marcus du Sautoy. It is not part of the Oxford Mathematics Public Lectures series but its themes and topics touch not only on mathematics but the wider natural sciences and beyond. All are very welcome and there is no need to register.

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In this year’s Simonyi Lecture Geoffrey West discusses universal laws that govern everything from growth to mortality in plants, animals, cities and companies. These remarkable laws originate in the networks that sustain life from circulatory to social systems and help us address big, urgent questions from population explosion, urbanization, lifespan and cancer, to the accelerating pace of life and global sustainability. Why do we stop growing and live about 100 years rather than 1000, or just two like mice? Why do we sleep eight hours a day and not three like elephants? Why do all companies and people die whereas cities keep growing? How are these related to innovation, wealth creation, and “singularities”? And is any of this sustainable? 

Geoffrey West is a theoretical physicist whose primary interests have been in fundamental questions in physics, biology and social organizations  West is a distinguished professor at the Sante Fe Institute, where he served as the president from 2004-2008. He is author of the recent best-selling book 'Scale'.

Answering a question of Milnor, Grigorchuk constructed in the early eighties the
first examples of groups of intermediate growth, that is, finitely generated
groups with growth strictly between polynomial and exponential.
In  joint work with Laurent Bartholdi, we show that under a mild regularity assumption, any function greater than exp(n^a), where `a' is a solution of the equation
  2^(3-3/x)+ 2^(2-2/x)+2^(1-1/x)=2,
is a growth function of some group. These are the first examples of groups
of intermediate growth where the asymptotic of  the growth function is known.
Among applications of our results is the fact that any group of locally subexponential growth
can be embedded as a subgroup of some group of intermediate growth (some of these latter groups cannot be  subgroups in Grigorchuk groups).

In a recent work with Tianyi Zheng, we  provide  near optimal lower bounds
for Grigorchuk torsion groups, including the first Grigorchuk group. Our argument is by a construction of random walks with non-trivial Poisson boundary, defined by 
a measure with power law decay.

Recent tools make it possible to partition the space of rational Dehn 
surgery slopes for a knot (or in some cases a link) in a 3-manifold into 
domains over which the Heegaard Floer homology of the surgered manifolds 
behaves continuously as a function of slope. I will describe some 
techniques for determining the walls of discontinuity separating these 
domains, along with efforts to interpret some aspects of this structure 
in terms of the behaviour of co-oriented taut foliations. This talk 
draws on a combination of independent work, previous joint work with 
Jake Rasmussen, and work in progress with Rachel Roberts.