We aim to generate gene coexpression networks from gene expression data. In our networks, nodes represent genes and edges depict high positive correlation in their expression across different samples. Methods based on Pearson correlation are the most commonly used to generate gene coexpression networks. We propose the use of distance correlation as an effective alternative to Pearson correlation when constructing gene expression networks. Our methodology pipeline includes a thresholding step which allows us to discriminate which pairs of genes are coexpressed. We select the value of the threshold parameter by studying the stability of the generated network, rather than relying on exogenous biological information known a priori.

Identifying systemically important countries is crucial for global financial stability. In this work we use (multilayer) network methods to identify systemically important countries. We study the financial system as a multilayer network, where each layer represent a different type of financial investment between countries. To rank countries by their systemic importance, we implement MultiRank, as well a simplistic model of financial contagion. In this first model, we consider that each country has a capital buffer, given by the capital to assets ratio. After the default of an initial country, we model financial contagion with a simple rule: a solvent country defaults when the amount of assets lost, due to the default of other countries, is larger than its capital. Our results show that when we consider that there are various types of assets the ranking of systemically important countries changes. We make all our methods available by introducing a python library. Finally, we propose a more realistic model of financial contagion that merges multilayer network theory and the contingent claims sectoral balance sheet literature. The aim of this framework is to model the banking, private, and sovereign sector of each country and thus study financial contagion within the country and between countries.