Knots are isotopy classes of smooth embeddings of $S^1$ in to $S^3$. Intuitively a knot can be thought of as an elastic closed curve in space, that can be deformed without tearing. Oxford Mathematician Daniele Celoria explains.
"Knots are ubiquitous in the study of the topological and geometrical properties of manifolds with dimension $3$ and $4$. This is due to the fact that they can be used to prescribe the attachment instructions for the "building blocks" of these spaces, through a process known as surgery.