Thu, 02 Feb 2023
12:00
L1

Copolymer templating from a mathematical and physical perspective

Thomas Ouldridge and Benjamin Qureshi
(Imperial College)
Further Information

 

Thomas is a Reader in Biomolecular Systems in the Department of Bioengineering at Imperial College. He leads the "Principles of Biomolecular Systems" group. 'His group probes the fundamental principles underlying complex biochemical systems through theoretical modelling, simulation and experiment.' (Taken from his website: https://www.imperial.ac.uk/principles-of-biomolecular-systems/)

You can also learn more about their work via their blog here

Abstract

Biological systems achieve their complexity by processing and exploiting information stored in molecular copolymers such as DNA, RNA and proteins. Despite the ubiquity and power of this approach in natural systems, our ability to implement similar functionality in synthetic systems is very limited. In this talk, we will first outline a new mathematical framework for analysing general models of colymerisation for infinitely long polymers. For a given model of copolymerisation, this approach allows for the extraction of key quantities such as the sequence distribution, speed of polymerisation and the rate of molecular fuel consumption without resorting to simulation. Subsequently, we will explore mechanisms that allow for reliable copying of the information stored in finite-length template copolymers, before touching on recent experimental work in which these ideas are put into practice.  

Estimating the probability that a given vector is in the convex hull of a random sample
Hayakawa, S Oberhauser, H Lyons, T
Thu, 26 Jan 2023
12:00
L1

From network dynamics to graph-based learning

Mauricio Barahona
(Department of Mathematics, Imperial College London)
Further Information

Prof. Mauricio Barahona is Chair in Biomathematics and Director of the EPSRC Centre for Mathematics of Precision Healthcare at Imperial. He obtained his PhD at MIT, under Steve Strogatz, followed by a MEC Fellowship at Stanford and the Edison International Fellowship at Caltech. His research is in the development of mathematical and computational methods for the analysis of biological, social and engineering systems using ideas from graph theory, dynamical systems, stochastic processes, optimisation and machine learning.

Abstract

This talk will explore a series of topics and example applications at the interface of graph theory and dynamics, from synchronization and diffusion dynamics on networks, to graph-based data clustering, to graph convolutional neural networks. The underlying links are provided by concepts in spectral graph theory.

Thu, 19 Jan 2023
14:30
L1

Aerodynamics inside and out: Bird respiration and flocking

Leif Ristroph
(Courant Institute)

Note: we would recommend to join the meeting using the Zoom client for best user experience.

Further Information

Leif Ristroph is an Associate Professor of Mathematics at The Courant Institute, New York University.

'He is an experimental physicist and applied mathematician who specializes in fluid dynamics, with a particular emphasis on fluid-structure interactions as applied to biological and geophysical flows. His biophysical work includes studies of the aerodynamics and stabilization of insect flight as well as the hydrodynamics of schooling and flow-sensing in swimming fish. Relevant to geophysical flows, he is interested in problems ranging from instabilities of interfacial flows to the evolution of shape during fluid mechanical erosion.' (taken from https://math.nyu.edu/~ristroph/)

Selected Publications

L. Ristroph and S. Childress, "Stable hovering of a jellyfish-like flying machine", Journal of the Royal Society Interface 11, 20130992 (2014)

L. Ristroph, M. N.J. Moore, S. Childress, M.J. Shelley, and J. Zhang, "Sculpting of an erodible body by flowing water", Proceedings of the National Academy of Sciences 109, 19606 (2012)

B. Liu, L. Ristroph, A. Weathers, S. Childress, and J. Zhang, "Intrinsic stability of a body hovering in an oscillating airflow", Physical Review Letters 108, 068103 (2012)

Abstract

ife forms have devised impressive and subtle ways to exploit fluid flows. I’ll talk about birds as flying machines whose behaviors can give surprising insights into flow physics. One story explains how flocking interactions can help to bring flapping flyers into orderly formations. A second story involves the more subtle role of aerodynamics in the highly efficient breathing of birds, which is thought to be critical to their ability to fly.

 

Pure anti-de Sitter supergravity and the conformal bootstrap
Alday, L Chester, S Physical Review Letters volume 129 issue 21 (17 Nov 2022)
Fast bayesian inference with batch bayesian quadrature via kernel recombination
Adachi, M Hayakawa, S Jorgensen, M Oberhauser, H Osborne, M Proceedings of the 36th Conference on Neural Information Processing Systems (NeurIPS 2022) (09 Dec 2022)
Simulation of arbitrage-free implied volatility surfaces
Cont, R Vuletic, M (11 Dec 2022)

We invite applications for a Postdoctoral Research Associate to work with Professor Helen Byrne on an exciting new Cancer Research UK funded project, using mathematical and computational approaches to understand the impact of spatial heterogeneity on tumour growth and response to treatment. The position is available for 3 years and the post-holder will be based at the Mathematical Institute, University of Oxford.

We are seeking to appoint an experienced Deputy Head of Academic Administration to deliver a varied, complex and stimulating workstream, on a permanent, full-time basis. Although this post is based at the Mathematical Institute, the department may consider applications to work remotely for part of your weekly working hours.

Fri, 10 Feb 2023

14:00 - 15:00
L4

Making ice sheet models scale properly

Ed Bueler
(University of Alaska Fairbanks)
Abstract

My talk will attempt to capture the imperfect state of the art in high-resolution ice sheet modelling, aiming to expose the core performance-limiting issues.  The essential equations for modeling ice flow in a changing climate will be presented, assuming no prior knowledge of the problem.  These geophysical/climate problems are of both free-boundary and algebraic-equation-constrained character.  Current-technology models usually solve non-linear Stokes equations, or approximations thereof, at every explicit time-step.  Scale analysis shows why this current design paradigm is expensive, but building significantly faster high-resolution ice sheet models requires new techniques.  I'll survey some recently-arrived tools, some near-term improvements, and sketch some new ideas.

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