University of Oxford

I'll start with the definition of the first Grigorchuk group as an automorphism group on a binary tree. After that I give a short overview about what growth means, and what kinds of growth we know. On this occasion I will mention a few groups that have each kind of growth and also outline what the 'Gap Problem' was. Having explained this I will prove - or depending on the time sketch - why this Grigorchuk group has intermediate growth. Depending on the time I will maybe also mention one or two open problems concerning growth.

There are two competing notions for a normal subsystem of a (saturated) fusion system. A recent theorem of mine shows how the two notions are related. In this talk I will discuss normal subsystems and their properties, and give some ideas on why this might be useful or interesting.

The first part of Galois' Second Mémoire, less than three pages of manuscript written in 1830, is devoted to an amazing insight, far ahead of its time. Translated into modern mathematical language (and out of French), it is the theorem that a primitive soluble finite permutation group has prime-power degree. This, and Galois' ideas, and counterexamples to some of

them, will be my theme.

The visceral endoderm (VE) is an epithelium of approximately 200 cells

encompassing the early post-implantation mouse embryo. At embryonic day

5.5, a subset of around 20 cells differentiate into morphologically

distinct tissue, known as the anterior visceral endoderm (AVE), and

migrate away from the distal tip, stopping abruptly at the future

anterior. This process is essential for ensuring the correct orientation

of the anterior-posterior axis, and patterning of the adjacent embryonic

tissue. However, the mechanisms driving this migration are not clearly

understood. Indeed it is unknown whether the position of the future

anterior is pre-determined, or defined by the movement of the migrating

cells. Recent experiments on the mouse embryo, carried out by Dr.

Shankar Srinivas (Department of Physiology, Anatomy and Genetics) have

revealed the presence of multicellular ‘rosettes’ during AVE migration.

We are developing a comprehensive vertex-based model of AVE migration.

In this formulation cells are treated as polygons, with forces applied

to their vertices. Starting with a simple 2D model, we are able to mimic

rosette formation by allowing close vertices to join together. We then

transfer to a more realistic geometry, and incorporate more features,

including cell growth, proliferation, and T1 transitions. The model is

currently being used to test various hypotheses in relation to AVE

migration, such as how the direction of migration is determined, what

causes migration to stop, and what role rosettes play in the process.