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Aura Raulo (Ecological and Evolutionary Dynamics) and Marie-Claire Koschowitz (Vertebrate Palaeobiology) discuss their work and its mathematical challenges.

Aura Raulo

" Aura Raulo is a graduate student in Zoology Department working on transmission of symbiotic bacteria in the social networks of their animal hosts"
Title: Heaps in networks - How we share our microbiota through kisses
Abstract: Humans, like all vertebrates have a microbiome, a diverse community of symbiotic bacteria that live in and on us and are crucial for our functioning. These bacteria help us digest food, regulate our mood and function as a key part of our immune system. Intriguingly, while they are part of us, they are, unlike our other cells, in constant flux between us, challenging the traditional definition of a biological individual. Many of these bacteria need intimate social contact to be transmitted from human to human, making social network analysis tools handy in explaining their community dynamics.What then is a recipe for a ``good microbiome”? Theories and evidence implies that the most healthy and immunologically robust microbiome composition is both diverse, semi-stable and somewhat synchronized among closely interacting individuals, but little is known about what kind of transmission landscapes determine these bacterial cocktails. In my talk, I will present humanmicrobiome as a network trait: a metacommunity of cells shaped by an equilibrium of isolation and contact among their hosts. I propose that we do notnecessarily need to think of levels of life (e.g. cells, individuals, populations) as being neatly nested inside of each other. Rather, aggregations of cooperating cells (both bacteria and human cells) can be considered as mere tighter clusters in their interaction network, dynamically creating de novo defined units of life. I will present a few game theoretical evolutionary dilemmas following from this perspective and highlight outstanding questions in mapping how network position of the host translates into community composition of bacteria in flux.

Marie Koschowitz
“Marie Koschowitz is a PhD student in the Department of Zoology and the Department of Earth Sciences, working on comparative physiology and large scale evolutionary patterns in reptiles such as crocodiles, birds and dinosaurs."
Title: Putting the maths into dinosaurs – A zoologist's perspective
Abstract: Contemporary palaeontology is a subject area that often deals with sparse data.Therefore, palaeontologists became rather inventive in pursuit of getting the most out of what is available. If we find a dinosaur’s skull that shows prominent, but puzzling, bony ridges without any apparent function, how can we make meaningful interpretations of its purpose in the living animal that was? If we are confronted with a variety of partially preserved bones from animals looking anatomically similar, but not quite alike, how can we infer relationships in the absence of genetic data?Some methods that resolve these questions, such as finite element analysis, were borrowed from engineering. Others, like comparative phylogenetics or MCMC generalised mixed effects models, are even more directly based on mathematical computations. All of these approaches help us to calculate things like a raptors bite-force and understand the ins and outsof their skulls anatomy, or why pterosaurs and plesiosaurs aren’t exactly dinosaurs. This talk aims to presents a selection of current approaches to applied mathematics which have been inspired by interdisciplinary research – and to foster awareness of all the ways how mathematicians can get involved in “dinosaur research”, if they feel inclined to do so.


 

What actually happens when you submit an article to a journal? How does refereeing work in practice? How can you keep editors happy as an author or referee? How does one become a referee or editor? What does 'publication' mean with the internet and arXiv?

In this panel we'll discuss what happens between finishing writing a mathematical paper and its final (?) publication, looking at the various roles that people play and how they work best.

Featuring Helen Byrne, Rama Cont and Jonathan Pila.

 

The last Fridays@2 of the year will be the Prelims Preparation Lecture aimed at first-year undergraduates. Richard Earl and Vicky Neale will highlight some key points to be aware of as you prepare for exams, thinking both about exam technique and revision strategy, and a student will offer some tips from their personal experience.  This will complement the Friday@2 event in Week 2, on Managing exam anxiety.  As part of the Prelims Preparation session, we'll look through two past exam questions, giving tips on how to structure a good answer.  You'll find that most helpful if you've worked through the questions yourself beforehand, so this is advance notice so that you can slot the questions into your timetable for the next few days.  They are both from 2013, one is Q5 from Maths I (on the Groups and Group Actions course), and the other is Q3 from Maths IV (on the Dynamics course).  You can access these, and a large collection of other past Prelims exam questions, via the archive.

This week’s Fridays@2 session, led by Dr Richard Earl and Dr Vicky Neale, is intended to provide advice on exam preparation and how to approach the Part A and Part B exams.

This session is aimed at second years and third years who will be sitting exams this term. Next week’s Fridays@2 will be for first years and will look at preparing for Prelims papers.
 

This workshop will focus on the main causes of exam stress, anxiety and panic and look at practical strategies to manage and overcome these issues. We will also review strategies to best support exam preparation.

Dr Ruth Collins is a Chartered Psychologist who specialises in the management of anxiety and panic. She is also a trained mindfulness teacher and an associate of the Oxford Mindfulness Centre.

This year sees the 100th anniversary of Emmy Noether receiving her Habilitation and thus becoming the first women to be granted the right to teach and lecture at a university in Prussia (now Germany).  Noether shaped modern algebra and her influence was felt in many other fields including topology.

We will start by exploring what algebraic topology is, how the subject was shaped by algebra (under the influence of Noether), before considering some current challenges and applications.

How do you create a self-sustaining, flourishing academic community in a developing country? What kind of challenges need to be overcome to ensure that quality education becomes available? What can we do to help make it happen? In this talk, we will describe our experience visiting the University of Yangon in Myanmar. During the visit, we delivered a course to the academic staff, and discussed future collaborations between Oxford and Yangon, as well as further directions for Mathematical education in Myanmar, all the while marvelling at the wonders of the Burmese culture.

The puzzling phenonenon of wave localization refers to unexpected confinement of waves triggered by disorder in the propagating medium. Localization arises in many physical and mathematical systems and has many important implications and applications. A particularly important case is the Schrödinger equation of quantum mechanics, for which the localization behavior is crucial to the electrical properties of materials. Mathematically it is tied to exponential decay of eigenfunctions of operators instead of their expected extension throughout the domain. Although localization has been studied by physicists and mathematicians for the better part of a century, many aspects remain mysterious. In particular, the sort of deterministic quantitative results needed to predict, control, and exploit localization have remained elusive. This talk will focus on major strides made in recent years based on the introduction of the landscape function and its partner, the effective potential. We will describe these developments from the viewpoint of a computational mathematician who sees the landscape theory as a completely unorthodox sort of a numerical method for computing spectra.

Viruses encapsulate their genetic material into protein containers that act akin to molecular Trojan horses, protecting viral genomes between rounds of infection and facilitating their release into the host cell environment. In the majority of viruses, including major human pathogens, these containers have icosahedral symmetry. Mathematical techniques from group, graph and tiling theory can therefore be used to better understand how viruses form, evolve and infect their hosts, and point the way to novel antiviral solutions.

In this talk, I will present an overarching theory of virus architecture, that contains the seminal Caspar Klug theory as a special case and solves long-standing open problems in structural virology. Combining insights into virus structure with a range of different mathematical modelling techniques, such as Gillespie algorithms, I will show how viral life cycles can be better understood through the lens of viral geometry. In particular, I will discuss a recent model for genome release from the viral capsid. I will also demonstrate the instrumental role of the Hamiltonian path concept in the discovery of a virus assembly mechanism that occurs in many human pathogens, such as Picornaviruses – a family that includes the common cold virus– and Hepatitis B and C virus. I will use multi-scale models of a viral infection and implicit fitness landscapes in order to demonstrate that therapeutic interventions directed against this mechanism have advantages over conventional forms of anti-viral therapy. The talk will finish with a discussion of how the new mathematical and mechanistic insights can be exploited in bio-nanotechnology for applications in vaccination and gene therapy.

The subject of $p$-adic cohomologies is over fifty years old. Many new developments have recently occurred. I will mostly limit myself to discussing some pertaining to the de Rham-Witt complex. After recalling the historical background and the basic results, I will give an overview of the new approach of Bhatt, Lurie and Mathew.