Mon, 22 Apr 2024
15:30
L3

TBC

Prof Eduardo Abi Jaber
(Centre de Mathématiques Appliquées, École polytechnique )
Thu, 13 Jun 2024

12:00 - 13:00
L3

OCIAM TBC

Pedro M. Reis
(EPFL)

The join button will be published 30 minutes before the seminar starts (login required).

Thu, 02 May 2024

12:00 - 13:00
L3

OCIAM TBC

Steve Fitzgerald
(University of Leeds)

The join button will be published 30 minutes before the seminar starts (login required).

Thu, 16 May 2024

12:00 - 13:00
L3

OCIAM TBC

​Doireann O'Kiely
(University of Limerick)

The join button will be published 30 minutes before the seminar starts (login required).

Mon, 03 Jun 2024
15:30
L3

TBC

Prof Stephan Eckstein
(University of Tübingen)
Mon, 20 May 2024
15:30
L3

TBC

Josselin Garnier
(Centre de Mathematiques Appliquees, Ecole polytechnique, Institut Polytechnique de Paris)
Further Information

This is a joint seminar with OxPDE.

Fri, 07 Jun 2024

14:00 - 15:00
L3

Modeling the electromechanics of aerial electroreception

Dr Isaac Vikram Chenchiah
(School of Mathematics University of Bristol)
Abstract
Aerial electroreception is the ability of some arthropods (e.g., bees) to detect electric fields in the environment. I present an overview of our attempts to model the electromechanics of this recently discovered phenomenon and how it might contribute to the sensory biology of arthropods. This is joint work with Daniel Robert and Ryan Palmer.


 

Fri, 31 May 2024

14:00 - 15:00
L3

Cytoneme-mediated morphogenesis

Prof Paul Bressloff
(Dept of Mathematics Imperial College London)
Abstract

Morphogen protein gradients play an essential role in the spatial regulation of patterning during embryonic development.  The most commonly accepted mechanism of protein gradient formation involves the diffusion and degradation of morphogens from a localized source. Recently, an alternative mechanism has been proposed, which is based on cell-to-cell transport via thin, actin-rich cellular extensions known as cytonemes. It has been hypothesized that cytonemes find their targets via a random search process based on alternating periods of retraction and growth, perhaps mediated by some chemoattractant. This is an actin-based analog of the search-and-capture model of microtubules of the mitotic spindle searching for cytochrome binding sites (kinetochores) prior to separation of cytochrome pairs. In this talk, we introduce a search-and-capture model of cytoneme-based morphogenesis, in which nucleating cytonemes from a source cell dynamically grow and shrink until making contact with a target cell and delivering a burst of morphogen. We model the latter as a one-dimensional search process with stochastic resetting, finite returns times and refractory periods. We use a renewal method to calculate the splitting probabilities and conditional mean first passage times (MFPTs) for the cytoneme to be captured by a given target cell. We show how multiple rounds of search-and-capture, morphogen delivery, cytoneme retraction and nucleation events lead to the formation of a morphogen gradient. We proceed by formulating the morphogen bursting model as a queuing process, analogous to the study of translational bursting in gene networks. We end by briefly discussing current work on a model of cytoneme-mediated within-host viral spread.

Subscribe to L3