The impact of geometry and diffusion barriers in cell polarity and receptor dynamics
From 'omics data to landscapes: dimensionality reduction and clustering through geometric graphs
Alignment-free sequence and network comparison
Bayesian parameter estimation for stochastic dynamic biological models
Can puzzles self-assemble?
Abstract
A holy grail of nano-technology is to create truly complex, multi-component structures by self assembly.
Most self-assembly has focused on the creation of `structural complexity'. In my talk, I will discuss `Addressable Complexity': the creation of structures that contain hundreds or thousands of
distinct building blocks that all have to find their place in a 3D structure.
Inferring the order of events
Abstract
Mining massive amounts of sequentially ordered data and inferring structural properties is nowadays a standard task (in finance, etc). I will present some results that combine and extend ideas from rough paths and machine learning that allow to give a general non-parametric approach with strong theoretical guarantees. Joint works with F. Kiraly and T. Lyons.
An engineer's dive into Oxford Applied Maths, and becoming faculty at a Medical School
Abstract
In this talk, I am reflecting on the last 8 extremely enjoyable years I spent in the department (DPhil, OCIAM, 2008-2012, post-doc, WCMB, 2012-2016). My story is a little unusual: coming from an Engineering undergraduate background, spending 8 years in the Maths department, and now moving to a faculty position at the Medical School. However, I think it highlights well the enormous breadth and applicability of mathematics beyond traditional disciplinary boundaries. I will discuss different projects during my time in Oxford, focusing on time-series, signal processing, and statistical machine learning methods, with diverse applications in real-world problems.
Modelling Anti-Surfactants and Thixotropic Lubrication
Abstract
In the first part of the talk, I will describe a fluid-dynamical model for a "anti-surfactant" solution (such as salt dissolved in water) whose surface tension is an increasing function of bulk solvent concentration. In particular, I will show that this model is consistent with the standard model for surfactants, and predicts a novel instability for anti-surfactants not present for surfactants. Some further details are given in the recent paper by Conn et al. Phys. Rev. E 93 043121 (2016).
In the second part of the talk, I will formulate and analyse the governing equations for the flow of a thixotropic or antithixotropic fluid in a slowly varying channel. These equations are equivalent to the equations of classical lubrication theory for a Newtonian fluid, but incorporate the evolving microstructure of the fluid, described in terms of a scalar structure parameter. If time permits, I will seek draw some conclusions relevant to thixotropic flow in porous media. Some further details are given in the forthcoming paper by Pritchard et al. to appear in J Non-Newt. Fluid Mech (2016).
Asymptotic and Numerical Analysis of Carrier's Problem
Abstract
A computational and asymptotic analysis of the solutions of Carrier's problem is presented. The computations reveal a striking and beautiful bifurcation diagram, with an infinite sequence of alternating pitchfork and fold bifurcations as the bifurcation parameter tends to zero. The method of Kuzmak is then applied to construct asymptotic solutions to the problem. This asymptotic approach explains the bifurcation structure identified numerically, and its predictions of the bifurcation points are in excellent agreement with the numerical results. The analysis yields a novel and complete taxonomy of the solutions to the problem, and demonstrates that a claim of Bender & Orszag is incorrect.