Thu, 12 May 2022

15:30 - 16:30
L4

Representations of p-adic groups – with a twist

Jessica Fintzen
(Bonn University)
Abstract

The Langlands program is a far-reaching collection of conjectures that relate different areas of mathematics including number theory and representation theory. A fundamental problem on the representation theory side of the Langlands program is the construction of all (irreducible, smooth, complex or mod-$\ell$) representations of p-adic groups. I will provide an overview of our understanding of the representations of p-adic groups, with an emphasis on recent progress including joint work with Kaletha and Spice that introduces a twist to the story, and outline some applications.

Thu, 12 May 2022

14:00 - 15:00
L3

Direct solvers for elliptic PDEs

Gunnar Martinsson
(Univerity of Texas at Austin)
Abstract

That the linear systems arising upon the discretization of elliptic PDEs can be solved efficiently is well-known, and iterative solvers that often attain linear complexity (multigrid, Krylov methods, etc) have proven very successful. Interestingly, it has recently been demonstrated that it is often possible to directly compute an approximate inverse to the coefficient matrix in linear (or close to linear) time. The talk will argue that such direct solvers have several compelling qualities, including improved stability and robustness, the ability to solve certain problems that have remained intractable to iterative methods, and dramatic improvements in speed in certain environments.

After a general introduction to the field, particular attention will be paid to a set of recently developed randomized algorithms that construct data sparse representations of large dense matrices that arise in scientific computations. These algorithms are entirely black box, and interact with the linear operator to be compressed only via the matrix-vector multiplication.

Thu, 12 May 2022

12:00 - 13:00
L5

Quantitative De Giorgi methods in kinetic theory for non-local operators

Amélie Loher
(University of Cambridge)
Abstract

We derive quantitatively the weak and strong Harnack inequality for kinetic Fokker--Planck type equations with a non-local diffusion operator for the full range of the non-locality exponents in (0,1).  This implies Hölder continuity.  We give novel proofs on the boundedness of the bilinear form associated to the non-local operator and on the construction of a geometric covering accounting for the non-locality to obtain the Harnack inequalities.  Our results apply to the inhomogeneous Boltzmann equation in the non-cutoff case.

Thu, 12 May 2022

12:00 - 13:00
L1

Averaged interface conditions: evaporation fronts in porous media (Ellen Luckins) & Macroscopic Transport in Heterogeneous Porous Materials (Lucy Auton)

Lucy Auton & Ellen Luckins
(Mathematical Institute, University of Oxford)
Abstract

Macroscopic Transport in Heterogeneous Porous Materials

Lucy Auton

Solute transport in porous materials is a key physical process in a wide variety of situations, including contaminant transport, filtration, lithium-ion batteries, hydrogeological systems, biofilms, bones and soils. Despite the prevalence of solute transport in porous materials, the effect of microstructure on flow and transport remains poorly understood and improving our understanding of this remains a major challenge.  In this presentation, I consider a two-dimensional microstructure comprising an array of obstacles of smooth but arbitrary shape, the size and spacing of which can vary along the length of the porous medium, allowing for anisotropy.  I use a nontrivial extension to classical homogenisation theory via the method of multiple scales to rigorously upscale the novel problem involving cells of varying area. This results in simple effective continuum equations for macroscale flow and transport where the effect of the microscale geometry on the macroscopic transport and removal is encoded within these simple macroscale equations via effective parameters such as an effective local anisotropic diffusivity and an effective local adsorption rate.  For a simple example geometry I exploit the two degrees of microstructural freedom in this problem, obstacle size and obstacle spacing, to investigate scenarios of uniform porosity but heterogenous microstructure, noting the impact this heterogeneity has on filter efficiency. 

This model constitutes the development of the core framework required to consider other crucial problems such as solute transport within soft porous materials for which there does not currently exist a simple macroscale model where the effective diffusivity and removal depend on the microstructure. Further, via this methodology I will  derive a  bespoke model for fluoride and arsenic removal filters. With this model I will be able to optimise the design of fluoride-removal filters which are being deployed across rural India. The design optimisation will both increase filter lifespan and reduce filter cost, enabling more people to access safe drinking water

 

Averaged interface conditions: evaporation fronts in porous media

Ellen Luckins

Homogenisation methods are powerful tools for deriving effective PDE models for processes incorporating multiple length-scales. For physical systems in which interface processes are crucial to the overall system, we might ask how the microstructure impacts the effective interface conditions, in addition to the PDEs in the bulk. In this talk we derive an effective model for the motion of an evaporation front through porous media, combining homogenisation and boundary layer analysis to derive averaged interface conditions at the evaporation front. Our analysis results in a new effective parameter in the boundary conditions, which encodes how the shape and speed of the porescale evaporating interfaces impact the overall drying process.

Wed, 11 May 2022

16:00 - 17:00
L5

Acylindrical hyperbolicity via mapping class groups

Alice Kerr
(University of Oxford)
Abstract

We will give a fairly self contained introduction to acylindrically hyperbolic groups, using mapping class groups as a motivating example. This will be a mainly expository talk, the aim is to make my topology seminar talk in week 5 more accessible to people who are less familiar with these topics.

Wed, 11 May 2022

14:30 - 16:00
L4

Questions of collaboration and credit in D’Arcy Thompson’s 'On Growth and Form'

Deborah Kent
(University of St Andrews)
Abstract

The first edition of Thompson’s famous book On Growth and Form appeared in 1917. It has subsequently been regarded as a foundational work in mathematical biology and a revolutionary contribution to the field of morphology. Most existing literature credits Thompson as a lone genius who produced the 793 pages of the 1917 edition and 1116 pages of the 1942 edition. Thompson’s correspondence presents a very different picture of this tome as one arising from extensive and ongoing – perhaps sometimes unwitting? – collaboration.

Wed, 11 May 2022

13:00 - 14:30
L4

Refinements of G2 structures

Matthew Magill
(Uppsala)
Further Information

Note the unusual time 13:00.

Abstract

G2 structure manifolds are a key ingredient in supersymmetric compactifications on seven-manifolds. We will discuss the fact that G2 structure manifolds admit refinements in the form of almost contact (3-) structures.  In fact, there are infinite dimensional spaces of these structures. We will discuss topological and differential geometric aspects of (the space of) these refinements. We will then explore applications in physics, including supersymmetry enhancement. This is based on 2101.12605.

Tue, 10 May 2022

16:00 - 17:00
C1

Representing the string 2-group on Clifford von Neumann algebras.

Peter Kristel
(University of Manitoba)
Abstract

The string 2-group is a fundamental object in string geometry, which is a refinement of spin geometry required to describe the spinning string. While many models for the string 2-group exist, the construction of a representation for it is new. In this talk, I will recall the notion of strict 2-group, and then give two examples: the automorphism 2-group of a von Neumann algebra, and the string 2-group. I will then describe the representation of the string 2-group on the hyperfinite III_1 factor, which is a functor from the string 2-group to the automorphism 2-group of the hyperfinite III_1 factor.

Tue, 10 May 2022

15:30 - 16:30
L4

Cohomological χ-independence for Higgs bundles and Gopakumar-Vafa invariants

Tasuki Kinjo
(University of Tokyo)
Abstract

In this talk, I will introduce the BPS cohomology of the moduli space of Higgs bundles on a smooth projective curve of rank r and degree d using cohomological Donaldson-Thomas theory. The BPS cohomology and the intersection cohomology coincide when r and d are coprime, but they are different in general. We will see that the BPS cohomology does not depend on d. This is a generalization of the Hausel-Thaddeus conjecture to non-coprime case. I will also explain that Toda's χ-independence conjecture (and hence the strong rationality conjecture) for local curves can be proved in the same manner. This talk is based on a joint work with Naoki Koseki and another joint work with Naruki Masuda.

Tue, 10 May 2022

15:30 - 16:30
L6

Random matrix theory as a tool for analysing biological data

Anna Maltsev
(Queen Mary University)
Abstract

The sinoatrial node (SAN) is the pacemaker region of the heart.
Recently calcium signals, believed to be crucially important in heart
rhythm generation, have been imaged in intact SAN and shown to be
heterogeneous in various regions of the SAN. However, calcium imaging
is noisy, and the calcium signal heterogeneity has not been
mathematically analyzed to distinguish meaningful signals from
randomness or to identify signalling regions in an objective way. In
this work we apply methods of random matrix theory (RMT) developed for
financial data and used for analysis of various biological data sets
including β-cell collectives and EEG data. We find eigenvalues of the
correlation matrix that deviate from RMT predictions, and thus are not
explained by randomness but carry additional meaning. We use
localization properties of the eigenvectors corresponding to high
eigenvalues to locate particular signalling modules. We find that the
top eigenvector captures a common response of the SAN to action
potential. In some cases, the eigenvector corresponding to the second
highest eigenvalue appears to yield a possible pacemaker region as its
calcium signals predate the action potential. Next we study the
relationship between covariance coefficients and distance and find
that there are long range correlations, indicating intercellular
interactions in most cases. Lastly, we perform an analysis of nearest
neighbor eigenvalue distances and find that it coincides with the
universal Wigner surmise. On the other hand, the number variance,
which captures eigenvalue correlations, is a parameter that is
sensitive to experimental conditions. Thus RMT application to SAN
allows to remove noise and the global effects of the action potential
and thereby isolate the correlations in calcium signalling which are
local. This talk is based on joint work with Chloe Norris with a
preprint found here:
https://www.biorxiv.org/content/10.1101/2022.02.25.482007v1.

Tue, 10 May 2022

14:00 - 15:00
L4

A Ramsey problem in blowups of graphs

António Girão
(Oxford)
Abstract

For graphs $G$ and $H$, we say $G \stackrel{r}{\to} H$ if every $r$-colouring of the edges of $G$ contains a monochromatic copy of $H$. Let $H[t]$ denote the $t$-blowup of $H$. The blowup Ramsey number $B(G \stackrel{r}{\to} H;t)$ is the minimum $n$ such that $G[n] \stackrel{r}{\to} H[t]$. Fox, Luo and Wigderson refined an upper bound of Souza, showing that, given $G$, $H$ and $r$ such that $G \stackrel{r}{\to} H$, there exist constants $a=a(G,H,r)$ and $b=b(H,r)$ such that for all $t \in \mathbb{N}$, $B(G \stackrel{r}{\to} H;t) \leq ab^t$. They conjectured that there exist some graphs $H$ for which the constant $a$ depending on $G$ is necessary. We prove this conjecture by showing that the statement is true when $H$ is a $3$-chromatically connected, which includes all cliques on $3$ or more vertices. We are also able to show perhaps surprisingly that for any forest $F$ there is $f(F,t)$ such that  for any $G \stackrel{r}{\to} H$, $B(G \stackrel{r}{\to} H;t)\leq f(F,t)$ i.e. the function does not depend on the ground graph $G$. This is joint work with Robert Hancock.

Tue, 10 May 2022

14:00 - 15:00
C6

Extracting backbones from bipartite projections: comparing hard and soft constraints

Zachary Neal
(Michigan State University)
Abstract

Co-occurrence networks formed by bipartite projection are widely studied in many contexts, including politics (bill co-sponsorship), bibliometrics (paper co-authorship), ecology (species co-habitation), and genetics (protein co-expression). It is often useful to focus on the backbone, a binary representation that includes only the most important edges, however many different backbone extraction models exist. In this talk, I will demonstrate the "backbone" package for R, which implements many such models. I will also use it to compare two promising null models: the fixed degree sequence model (FDSM) that imposes hard constraints, and the stochastic degree sequence model (SDSM) that imposes soft constraints, on the bipartite degree sequences. While FDSM is more statistically powerful, SDSM is more efficient and offers a close approximation.

Tue, 10 May 2022

14:00 - 15:00
L6

Equivariance in Deep Learning

Sheheryar Zaidi and Bryn Elesedy
(Oxford)
Abstract

One core aim of (supervised) machine learning is to approximate an unknown function given a dataset containing examples of input-output pairs. Real-world examples of such functions include the mapping from an image to its label or the mapping from a molecule to its energy. For a variety of such functions, while the precise mapping is unknown, we often have knowledge of its properties. For example, the label of an image may be invariant to rotations of the input image. Generally, such properties formally correspond to the function being equivariant to certain actions on its input and output spaces. This has led to much research on building equivariant function classes (aka neural networks). In this talk, we survey this growing field of equivariance in deep learning for a mathematical audience, motivating the need for equivariance, covering concrete examples of equivariant neural networks, and offering a learning theoretic perspective on the benefits of equivariance. 

Tue, 10 May 2022

12:00 - 13:15
Virtual

From dS to AdS, and back

Charlotte Sleight
(Univeristy of Durham)
Abstract

In the search for a complete description of quantum mechanical and
gravitational phenomena, we are inevitably led to consider observables on
boundaries at infinity. This is the common mantra that there are no local
observables in quantum gravity and gives rise to the tantalising possibility
of a purely boundary--or holographic--description of physics in the
interior. The AdS/CFT correspondence provides an important working example
of these ideas, where the boundary description of quantum gravity in anti-de
Sitter (AdS) space is an ordinary quantum mechanical system-- in particular,
a Lorentzian Conformal Field Theory (CFT)--where the rules of the game are
well understood. It would be desirable to have a similar level of
understanding for the universe we actually live in. In this talk I will
explain some recent efforts that aim to understand the rules of the game for
observables on the future boundary of de Sitter (dS) space. Unlike in AdS,
the boundaries of dS space are purely spatial with no standard notion of
locality and time. This obscures how the boundary observables capture a
consistent picture of unitary time evolution in the interior of dS space. I

will explain how, despite this difference, the structural similarities
between dS and AdS spaces allow to forge relations between boundary
correlators in these two space-times. These can be used to import
techniques, results and understanding from AdS to dS.

 

 

Tue, 10 May 2022

10:00 - 12:00
L3

Regularity Theory of Spaces with Lower Ricci Curvature Bounds

Daniele Semola
(Oxford University)
Further Information

Aimed at: people interested on Geometric Analysis, Geometric Measure Theory and regularity theory in Partial Differential Equations.

Prerequisites: Riemannian and Differential Geometry, Metric spaces, basic knowledge of Partial Differential Equations.


Outline of the course:

  • Lecture 1:
    • Quick introduction to non-smooth spaces with lower Ricci curvature bounds [1, 23, 20, 17];
    • Basic properties of spaces with lower Ricci bounds: Bishop-Gromov inequality and doubling metric measure spaces, Bochner’s inequality, splitting theorem [19, 22];
    • Convergence and stability: Gromov-Hausdorff convergence, Gromov pre-compactness theorem, stability and tangent cones [19, 22];
  • Lecture 2:
    • Functional form of the splitting theorem via splitting maps;
    • δ-splitting maps and almost splitting theorem [5, 7];
    • Definition of metric measure cone, stability of RCD property for cones [16];
    • Functional form of the volume cone implies metric cone [12];
    • Almost volume cone implies almost metric cone via stability.
  • Lecture 3:
    • Maximal function type arguments;
    • Existence of Euclidean tangents;
    • Rectifiability and uniqueness of tangents at regular points [18];
    • Volume convergence [9, 13];
    • Tangent cones are metric cones on noncollapsed spaces [5, 6, 13].
  • Lecture 4:
    • Euclidean volume rigidity [9, 6, 13];
    • ε-regularity and classical Reifenberg theorem [6, 15, 7];
    • Harmonic functions on metric measure cones, frequency and separation of variables [7];
    • Transformation theorem for splitting maps [7];
    • Proof of canonical Reifenberg theorem via harmonic splitting maps [7].
  • Lecture 5:
    • Regular and singular sets [6, 13];
    • Stratification of singular sets [6, 13];
    • Examples of singular behaviours [10, 11];
    • Hausdorff dimension bounds via Federer’s dimension reduction [6, 13];
    • Quantitative stratification of singular sets [8];
    • An introduction to quantitative differentiation [3];
    • Cone splitting principle [8];
    • Quantitative singular sets and Minkowski content bounds [8].
  • Lecture 6:
    • The aim of this lecture is to give an introduction to the most recent developments of the regularity theory for non collapsed Ricci limit spaces. We will introduce the notion of neck region in this context and then outline how they have been used to prove rectifiability of singular sets in any codimension for non collapsed Ricci limit spaces by Cheeger-Jiang-Naber [7].
Abstract

The aim of this course is to give an introduction to the regularity theory of non-smooth spaces with lower bounds on the Ricci Curvature. This is a quickly developing field with motivations coming from classical questions in Riemannian and differential geometry and with connections to Probability, Geometric Measure Theory and Partial Differential Equations.


In the lectures we will focus on the non collapsed case, where much sharper results are available, mainly adopting the synthetic approach of the RCD theory, rather than following the original proofs.


The techniques used in this setting have been applied successfully in the study of Minimal surfaces, Elliptic PDEs, Mean curvature flow and Ricci flow and the course might be of interest also for people working in these subjects.

Mon, 09 May 2022

16:00 - 17:00
C1

An Overview of Geometric Class Field Theory

Aaron Slipper
(University of Chicago)
Abstract

In this talk, I would like to discuss Deligne’s version of Geometric Class Field theory, with special emphasis on the correspondence between rigidified 1-dimensional l-adic local systems on a curve and 1-dimensional l-adic local systems on Pic with certain compatibilities. We should like to give a sense of how this relates to the OG class field theory, and how Deligne demonstrates this correspondence via the geometry of the Abel-Jacobi Map. If time permits, we would also like to discuss the correspondence between continuous 1-dimensional l-adic representations of the etale fundamental group of a curve and local systems.

Mon, 09 May 2022

15:30 - 16:30
L4

Automorphisms of free groups and the spaces which they act on.

Armando Martino
(Southampton)
Abstract

We will review some open questions about automorphisms of free groups, give some partial answers, and explain the deformation spaces of trees that they act on, as well as the geometry of these spaces arising from the Lipschitz metric. This will be a gentle introduction to the topic, focused on introducing the concepts.

 

Mon, 09 May 2022

15:30 - 16:30
L3

Exploration-exploitation trade-off for continuous-time episodic reinforcement learning with linear-convex models

LUKASZ SZPRUCH
(University of Edinburgh)
Abstract

 We develop a probabilistic framework for analysing model-based reinforcement learning in the episodic setting. We then apply it to study finite-time horizon stochastic control problems with linear dynamics but unknown coefficients and convex, but possibly irregular, objective function. Using probabilistic representations, we study regularity of the associated cost functions and establish precise estimates for the performance gap between applying optimal feedback control derived from estimated and true model parameters. We identify conditions under which this performance gap is quadratic, improving the linear performance gap in recent work [X. Guo, A. Hu, and Y. Zhang, arXiv preprint, arXiv:2104.09311, (2021)], which matches the results obtained for stochastic linear-quadratic problems. Next, we propose a phase-based learning algorithm for which we show how to optimise exploration-exploitation trade-off and achieve sublinear regrets in high probability and expectation. When assumptions needed for the quadratic performance gap hold, the algorithm achieves an order (N‾‾√lnN) high probability regret, in the general case, and an order ((lnN)2) expected regret, in self-exploration case, over N episodes, matching the best possible results from the literature. The analysis requires novel concentration inequalities for correlated continuous-time observations, which we derive.

 

-----------------------------------------------------------------------
Dr Lukasz Szpruch

Mon, 09 May 2022
14:15
L5

Conformally Invariant Energies of Curves and Surfaces

Alexis Michelat
(Oxford University)
Abstract

The integral of mean curvature squared is a conformal invariant of surfaces reintroduced by Willmore in 1965 whose study exercised a tremendous influence on geometric analysis and most notably on minimal surfaces in the last years.


On the other hand, the Loewner energy is a conformal invariant of planar curves introduced by Yilin Wang in 2015 which is notably linked to SLE processes and the Weil-Petersson class of (universal) Teichmüller theory.


In this presentation, after a brief historical introduction, we will discuss some recent developments linking the Willmore energy to the Loewner energy and mention several open problems.


Joint work with Yilin Wang (MIT/MSRI)

Mon, 09 May 2022

12:45 - 13:45
L1

Topological defects and generalised orbifolds

Ingo Runkel
(University of Hamburg)
Abstract

Topological defects in quantum field theory can be understood as a generalised notion of symmetry, where the operation is not required to be invertible. Duality transformations are an important example of this. By considering defects of various dimensions, one is naturally led to more complicated algebraic structures than just groups. So-called 2-groups are a first instance, which arise from invertible defects of codimension 1 and 2. Without invertibility one arrives at so-called "fusion categories”. I would like to explain how one can "gauge" such non-invertible symmetries in the case of topological field theories, and I will focus on results in two and three dimensions. This talk is based on joint work with Nils Carqueville, Vincentas Mulevicius, Gregor Schaumann, and Daniel Scherl.

Fri, 06 May 2022

16:00 - 17:00
L5

On-shell Correlators and Color-Kinematics Duality in Curved Spacetimes

Allic Sivaramakrishnan
(University of Kentucky)
Further Information

It is also possible to join online via Zoom.

Abstract

We define a perturbatively calculable quantity—the on-shell correlator—which furnishes a unified description of particle dynamics in curved spacetime. Specializing to the case of flat and anti-de Sitter space, on-shell correlators coincide precisely with on-shell scattering amplitudes and boundary correlators, respectively. Remarkably, we find that symmetric manifolds admit a generalization of on-shell kinematics in which the corresponding momenta are literally the isometry generators of the spacetime acting on the external kinematic data. These isometric momenta are intrinsically non-commutative but exhibit on-shell conditions that are identical to those of flat space, thus providing a common language for computing and representing on-shell correlators which is agnostic about the underlying geometry. 

As applications of these tools, we compute n-point scalar correlators in AdS in terms of isometric momenta. In many cases, the results are direct lifts of flat-space expressions. We provide field-theoretic proofs of color-kinematics duality and BCJ relations in AdS at n-points in biadjoint scalar theory and the nonlinear sigma model. We discuss possible extensions to generic curved spacetimes without symmetry.

Fri, 06 May 2022

15:00 - 16:00
L4

Applied Topology TBC

Bernadette Stolz
(University of Oxford, Mathematical Institute)
Fri, 06 May 2022

14:00 - 15:00
N3.12

Once and Twice Categorified Algebra

Thibault Décoppet
(University of Oxford)
Abstract

I will explain in what sense the theory of finite tensor categories is a categorification of the theory of finite dimensional algebras. In particular, I will introduce finite module categories, review a key result of Ostrik, and present Morita theory for finite categories. I will give many examples to illustrate these ideas. Then, I will explain the elementary properties of finite braided tensor categories. If time permits, I will also mention my own work, which consists in categorifying these ideas once more!

Fri, 06 May 2022

14:00 - 15:00
L4

Lahars and huaicos: modelling erosive flash floods

Andrew Hogg
(Bristol University)
Abstract

Lahars and huaicos are potent natural hazards that threaten lives and livelihoods. They comprise debris-laden fluid that flows rapidly down slopes, bulking up considerably as they progress. Owing to their rapid onset and the significant threat that they pose to communities and infrastructures, it is important to be able to predict their motion in order to assess quantitatively some of the impacts that they may cause. In this seminar I will present mathematical models of these flows and apply them to various natural settings, drawing on examples from Peru and the Philippines.  Along the way I will show some informative, idealised solutions, the susceptibility of these flows to roll wave instabilities, ways to prevent ill-posedness and how to include measured topography in the computation.

Fri, 06 May 2022

14:00 - 15:00
L6

Intrinsic instability of the dysbiotic microbiome revealed through dynamical systems inference at ecosystem-scale

Dr Travis Gibson
(Harvard Medical School)
Abstract

Dynamical systems models are a powerful tool for analyzing interactions in ecosystems and their intrinsic properties such as stability and resilience. The human intestinal microbiome is a complex ecosystem of hundreds of microbial species, critical to our health, and when in a disrupted state termed dysbiosis, is involved in a variety of diseases.  Although dysbiosis remains incompletely understood, it is not caused by single pathogens, but instead involves broader disruptions to the microbial ecosystem.  Dynamical systems models would thus seem a natural approach for analyzing dysbiosis, but have been hampered by the scale of the human gut microbiome, which constitutes hundreds of thousands of potential ecological interactions, and is profiled using sparse and noisy measurements. Here we introduce a combined experimental and statistical machine learning approach that overcomes these challenges to provide the first comprehensive and predictive model of microbial dynamics at ecosystem-scale. We show that dysbiosis is characterized by competitive cycles of interactions among microbial species, in contrast to the healthy microbiome, which is stabilized by chains of positive interactions initiated by resistant starch-degrading bacteria. To achieve these results, we created cohorts of “humanized” gnotobiotic mice via fecal transplantation from healthy and dysbiotic human donors, and subjected mice to dietary and antibiotic perturbations, in the densest temporal interventional study to date. We demonstrate that our probabilistic machine learning method achieves scalability while maintaining interpretability on these data, by inferring a small number of modules of bacterial taxa that share common interactions and responses to perturbations. Our findings provide new insights into the mechanisms of microbial dysbiosis, have potential implications for therapies to restore the microbiome to treat disease, and moreover offer a powerful framework for analyzing other complex ecosystems.