The classical Minkowski problem consists in finding a convex polyhedron from data consisting of normals to their faces and their surface areas. In the smooth case, the corresponding problem for convex bodies is to find the convex body given the Gauss curvature of its boundary, as a function of the unit normal. The proof consists of three parts: existence, uniqueness and regularity. 

In this talk, we study a Minkowski problem for certain measure, called p-capacitary surface area measure, associated to a compact convex set $E$ with nonempty interior and its $p-$harmonic capacitary function (solution to the p-Laplace equation in the complement of $E$).  If $\mu_p$ denotes this measure, then the Minkowski problem we consider in this setting is that; for a given finite Borel positive measure $\mu$ on $\mathbb{S}^{n-1}$, find necessary and sufficient conditions for which there exists a convex body $E$ with $\mu_p =\mu$. We will discuss the existence, uniqueness, and regularity of this problem which have deep connections with the Brunn-Minkowski inequality for p-capacity and Monge-Amp{\`e}re equation.

The parabolic Allen-Cahn equations is the gradient flow of phase transition energy and can be viewed as a diffused version of mean curvature flows of hypersurfaces. It has been known by the works of Ilmanen and Tonegawa that the energy densities of the Allen-Cahn flows converges to mean curvature flows in the sense of varifold and the limit varifold is integer rectifiable. It is not known in general whether the transition layers have higher regularity of convergence yet. In this talk, I will report on a joint work with Huy Nguyen that under the low entropy condition, the convergence of transition layers can be upgraded to C^{2,\alpha} sense. This is motivated by the work of Wang-Wei and Chodosh-Mantoulidis in elliptic case that under the condition of stability, one can upgrade the regularity of convergence.

This talk aims to provide a simple introduction on how to probe the
explicit geometry of certain moduli schemes arising in enumerative
geometry. Stable pairs, introduced by Pandharipande and Thomas in 2009, offer a curve-counting theory which is tamer than the Hilbert scheme of
curves used in Donaldson-Thomas theory. In particular, they exclude
curves with zero-dimensional or embedded components.

Ribbons are non-reduced schemes of dimension one, whose non-reduced
structure has multiplicity two in a precise sense. Following Ferrand, Banica, and Forster, there are several results on how to construct
ribbons (and higher non-reduced structures) from the data of line
bundles on a reduced scheme. With this approach, we can consider stable
pairs whose underlying curve is a ribbon: the remaining data is
determined by allowing devenerations of the line bundle defining the
double structure.

Femoral neck response to physiological loading during level walking can be better understood, if personalized muscle and bone anatomy is considered. Finite element (FE) models of in vivo cadaveric bones combined with gait data from body-matched volunteers were used in the earlier studies, which could introduce errors in the results. The aim of the current study is to report the first fully personalized multiscale model to investigate the strains predicted at the femoral neck during a full gait cycle. CT-based Finite element models (CT/FE) of the right femur were developed following a validated framework. Muscle forces estimated by the musculoskeletal model were applied to the CT/FE model. For most of the cases, two overall peaks were predicted around 15% and 50% of the gait. Maximum strains were predicted at the superior neck region in the model. Anatomical muscle variations seem to affect femur response leading to considerable variations among individuals, both in term of the strains level and the trend at the femoral neck.
 

Pattern formation emerges during development from the interplay between gene regulatory networks (GRNs) acting at the single cell level and cell movements driving tissue level morphogenetic changes. As a result, the timing of cell specification and the dynamics of morphogenesis must be tightly cross-regulated. In the developing zebrafish, mesoderm progenitors will spend varying amounts of time (from 5 to 10hrs) in the tailbud before entering the pre-somitic mesoderm (PSM) and initiating a stereotypical transcriptional trajectory towards a mesodermal fate. In contrast, when dissociated and placed in vitro, these progenitors differentiate synchronously in around 5 hours. We have used a data-driven mathematical modelling approach to reverse-engineer a GRN that is able to tune the timing of mesodermal differentiation as progenitors leave the tailbud’s signalling environment, which also explains our in vitro observations. This GRN recapitulates pattern formation at the tissue level when modelled on cell tracks obtained from live-imaging a developing PSM. Our “live-modelling” framework also allows us to simulate how perturbations to the GRN affect the emergence of pattern in zebrafish mutants. We are now extending this analysis to cichlid fishes in order to explore the regulation of developmental time in evolution.