Tue, 30 Nov 2021
12:30
C5

Modelling high-speed droplet impact onto an elastic membrane (Negus). Lubrication model of a valve-controlled, gravity-driven bioreactor (Saville)

Michael Negus & Helen Saville
(Mathematical Institute (University of Oxford))
Abstract

Michael Negus

Modelling high-speed droplet impact onto an elastic membrane

The impact of a high-speed droplet onto an elastic membrane is a highly nonlinear process and poses a formidable modelling challenge due to both the multi-scale nature of the flow and the fluid-structure interaction between the droplet and the membrane. We present two modelling approaches for droplet impact onto elastic membranes: matched asymptotics and direct numerical simulations (DNS). Inviscid Wagner theory is used in the former to derive analytical expressions which approximate the behaviour of the droplet during the early stages of impact, while the DNS builds on the open-source volume-of-fluid code Basilisk. We demonstrate the strong influence that the thickness, tension and stiffness of the membrane have on the dynamics of the droplet and the membrane. We also quantitatively show that the speed the droplet spreads across the substrate is notably decreased when the membrane is more compliant, which is consistent with experimental findings that splashing can be inhibited by impacting onto a soft substrate. We conclude by showing how these methods are complementary, as a combination of both can lead to a thorough understanding of the droplet impact across timescales.

Helen Saville

Lubrication model of a valve-controlled, gravity-driven bioreactor

Hospitals sometimes experience shortages of donor blood platelet supplies, motivating research into in vitro production of platelets. We model a novel platelet bioreactor described in Shepherd et al. [1]. The bioreactor consists of an upper channel, a lower channel, and a cell-seeded porous collagen scaffold situated between the two. Flow is driven by gravity, and controlled by valves on the four inlets and outlets. The bioreactor is long relative to its width, a feature which we exploit to derive a lubrication reduction of Navier-Stokes flow coupled to Darcy. Models for two cases are considered: small amplitude valve oscillations, and order one amplitude valve oscillations. The former model is a systematic reduction; the latter incorporates a phenomenological approximation for the cross-sectional flow profile. As the shear stress experienced by cells influences platelet production, we use our model to quantify the effect of valve dynamics on shear stress.

1: Shepherd, J.H., Howard, D., Waller, A.K., Foster, H.R., Mueller, A., Moreau, T., Evans, A.L., Arumugam, M., Chalon, G.B., Vriend, E. and Davidenko, N., Biomaterials, 182, pp.135-144. (2018)

Mon, 06 Jun 2022
14:15
L5

Symplectic cohomology of compound Du Val singularities

Jonny Evans
(University of Lancaster)
Abstract

(Joint with Y. Lekili) If someone gives you a variety with a singular point, you can try and get some understanding of what the singularity looks like by taking its “link”, that is you take the boundary of a neighbourhood of the singular point. For example, the link of the complex plane curve with a cusp $y^2 = x^3$ is a trefoil knot in the 3-sphere. I want to talk about the links of a class of 3-fold singularities which come up in Mori theory: the compound Du Val (cDV) singularities. These links are 5-dimensional manifolds. It turns out that many cDV singularities have the same 5-manifold as their link, and to tell them apart you need to keep track of some extra structure (a contact structure). We use symplectic cohomology to distinguish the contact structures on many of these links.

Mon, 29 Nov 2021

16:00 - 17:00
C1

Convex Functions and Additive Structure

Peter Bradshaw
Abstract

It is a widely accepted philosophy in additive number theory that convex sets ought not to exhibit much additive structure. We could measure this by estimating the sizes of their sumsets. In this talk, we will hopefully move from the philosophical to the concrete, by giving ways to see that convex sets and functions have poor additive structure. We will also discuss some recent developments in the area.

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