Mathematical models of blood pressure regulation
Order under uncertainty: probabilistic approaches to pseudotime estimation from single cell gene expression measurements
Bringing together experimental and computational methods for the study of vascular development
Qualitative behaviour of stochastic and deterministic models of biochemical reaction networks
Abstract
If the abundances of the constituent molecules of a biochemical reaction system are sufficiently high then their concentrations are typically modelled by a coupled set of ordinary differential equations (ODEs). If, however, the abundances are low then the standard deterministic models do not provide a good representation of the behaviour of the system and stochastic models are used. In this talk, I will first introduce both the stochastic and deterministic models. I will then provide theorems that allow us to determine the qualitative behaviour of the underlying mathematical models from easily checked properties of the associated reaction network. I will present results pertaining to so-called ``complex-balanced'' models and those satisfying ``absolute concentration robustness'' (ACR). In particular, I will show how ACR models, which are stable when modelled deterministically, necessarily undergo an extinction event in the stochastic setting. I will then characterise the behaviour of these models prior to extinction.
Learning about HIV's ecology from sequence data
Uncertainty and sensitivity analysis of cardiac cell models -- insights from Gaussian process emulators
Symplectic categories in Derived Geometry
Abstract
I will describe a construction of the Weinstein symplectic category of Lagrangian correspondences in the context of shifted symplectic geometry. I will then explain how one can linearize this category starting from a "quantization" of (-1)-shifted symplectic derived stacks: we assign a perverse sheaf to each (-1)-shifted symplectic derived stack (already done by Joyce and his collaborators) and a map of perverse sheaves to each (-1)-shifted Lagrangian correspondence (still conjectural).