Prof. Helen Byrne

DPhil, MSc, BA/MA

Status

Academic Faculty

Professor of Applied Mathematics

Tutorial Fellow, Keble College

Previous Roles:

Examiner for Final Honour School Mathematics (Panel B)

Associate Head of Department, Planning and Equality and Diversity

Senior Mathematics Tutor, Keble College

Director of Equality and Diversity, MPLS Division

Contact form

+44 1865 615149

ORCID iD

https://orcid.org/0000-0003-1771-5910

Research groups

Mathematical Biology

Address
Mathematical Institute
University of Oxford
Andrew Wiles Building
Radcliffe Observatory Quarter
Woodstock Road
Oxford
OX2 6GG

Recent publications

Algebra, Geometry and Topology of ERK Kinetics.

Marsh, L Dufresne, E Byrne, H Harrington, H Bulletin of mathematical biology volume 84 issue 12 137- (23 Oct 2022)

Spatio-temporal modelling of phenotypic heterogeneity in tumour tissues and its impact on radiotherapy treatment.

Celora, G Byrne, H Kevrekidis, P J Theor Biol 111248- (20 Sep 2022)

Dynamic fibronectin assembly and remodeling by leader neural crest cells
prevents jamming in collective cell migration

Martinson, W McLennan, R Teddy, J McKinney, M Davidson, L Baker, R Byrne, H Kulesa, P Maini, P (16 Sep 2022) http://arxiv.org/abs/2209.07794v1

In vitro and in silico approaches to engineering three-dimensional biological tissues and organoids

Byrne, H Interface Focus volume 12 issue 5 (12 Aug 2022)

Combining mechanisms of growth arrest in solid tumours: a mathematical investigation

Colson, C Byrne, H Maini, P Bulletin of Mathematical Biology volume 84 (01 Jul 2022)

Teaching

M5: Multivariable calculus
B5.2: Applied Partial Differential Equations
B5.5: Further Mathematical Biology

Research interests

My research focuses on the development and analysis of mathematical and computational models that describe biomedical systems, with particular application to the growth and treatment of solid tumours, wound healing and tissue engineering. My aims in studying such models are two-fold: to identify the mechanisms responsible for observed biomedical phenomena and to abstract from the resulting mathematical models novel features that merit theoretical investigation.

Preferred address

Mathematical InstituteUniversity of OxfordOxford OX2 6GG

Prizes, awards, and scholarships

2019: Leah Edelstein-Keshet Prize (Senior Award), Society for Mathematical Biology

2020: Fellow of the Society for Mathematical Biology

Major / recent publications

MO Bernabeu, J Kory, JA Grogan, B Markelc, A Beardo, M d’Avezac, R Enjalbert, J Kaeppler, N Daly, J Hetherington, T Krueger, PK Maini, JM Pitt-Francis, RJ Muschel, T Alarcon and HM Byrne (2020). Abnormal morphology biases haematocrit distribution in tumour vasculature and contributes to heterogeneity in tissue oxygenation. PNAS 117 (45) 27811-27819.
A Osojnik, EA Gaffney, M Davies, JWT Yates, HM Byrne (2020). Identifying and characterising the impact of excitability in a mathematical model of tumour-immune interactions. J Theor Biol 501: 110250
TD Lewin, PK Maini, EG Moros, H Enderling and HM Byrne (2019). A three-phase model to investigate the effects of dead material on the growth of avascular tumours. Mathematical Modelling of Natural Phenomena 15: 22.
HZ Ford, HM Byrne and MR Myerscough (2019). A lipid-structured model for macrophage populations in atherosclerotic plaques. J Theor Biol 479: 48-63.
MJ Chen, LS Kimpton, JP Whiteley, M Castilho, J Malda, CP Please, SL Waters and HM Byrne (2018). Multiscale modelling and homogenisation of fibre-reinforced hydrogels for tissue engineering. European Journal of Applied Mathematics, 1-29. (doi:10.1017/S0956792518000657).
JA Grogan, AJ Connor, JM Pitt-Frances, PK Maini and HM Byrne (2018). The importance of geometry in the corneal micropocket angiogenesis assay. PLoS Comp Biol 14(3): e1006049.
S Pillay, HM Byrne and PK Maini (2018). The impact of volume exclusion processes on angiogenesis models. J Math Biol. 77(6-7): 1721-1759.
B Lambert, AL MacLean, AG Fletcher, AN Combes, MH Little, HM Byrne (2018). Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis. J Math Biol 76(7): 1673-1697.
SK Kay, HA Harrington, S Shepherd, K Brennan, T Dale, JM Osborne, DJ Gavaghan, HM Byrne (2017). The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt. PLoS Comp Biol. 13(2): e1005400.
AL MacLean, Z Rosen, HM Byrne, HA Harrington (2015). Parameter-free methods distinguish Wnt pathway models and guide design of experiments. PNAS, 10.1073/pnas.1416655112