Prof. Helen Byrne

DPhil, MSc, BA/MA

Status

Academic Faculty

Professor of Applied Mathematics

Tutorial Fellow, Keble College

Previous Roles:

Examiner for Final Honour School Mathematics (Panel B)

Associate Head of Department, Planning and Equality and Diversity

Senior Mathematics Tutor, Keble College

Director of Equality and Diversity, MPLS Division

+44 1865 615149

Contact form

ORCID iD

https://orcid.org/0000-0003-1771-5910

Research groups

Mathematical Biology

Address

Mathematical Institute
University of Oxford
Andrew Wiles Building
Radcliffe Observatory Quarter
Woodstock Road
Oxford
OX2 6GG

Major / recent publications

MO Bernabeu, J Kory, JA Grogan, B Markelc, A Beardo, M d’Avezac, R Enjalbert, J Kaeppler, N Daly, J Hetherington, T Krueger, PK Maini, JM Pitt-Francis, RJ Muschel, T Alarcon and HM Byrne (2020). Abnormal morphology biases haematocrit distribution in tumour vasculature and contributes to heterogeneity in tissue oxygenation. PNAS 117 (45) 27811-27819.
A Osojnik, EA Gaffney, M Davies, JWT Yates, HM Byrne (2020). Identifying and characterising the impact of excitability in a mathematical model of tumour-immune interactions. J Theor Biol 501: 110250
TD Lewin, PK Maini, EG Moros, H Enderling and HM Byrne (2019). A three-phase model to investigate the effects of dead material on the growth of avascular tumours. Mathematical Modelling of Natural Phenomena 15: 22.
HZ Ford, HM Byrne and MR Myerscough (2019). A lipid-structured model for macrophage populations in atherosclerotic plaques. J Theor Biol 479: 48-63.
MJ Chen, LS Kimpton, JP Whiteley, M Castilho, J Malda, CP Please, SL Waters and HM Byrne (2018). Multiscale modelling and homogenisation of fibre-reinforced hydrogels for tissue engineering. European Journal of Applied Mathematics, 1-29. (doi:10.1017/S0956792518000657).
JA Grogan, AJ Connor, JM Pitt-Frances, PK Maini and HM Byrne (2018). The importance of geometry in the corneal micropocket angiogenesis assay. PLoS Comp Biol 14(3): e1006049.
S Pillay, HM Byrne and PK Maini (2018). The impact of volume exclusion processes on angiogenesis models. J Math Biol. 77(6-7): 1721-1759.
B Lambert, AL MacLean, AG Fletcher, AN Combes, MH Little, HM Byrne (2018). Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis. J Math Biol 76(7): 1673-1697.
SK Kay, HA Harrington, S Shepherd, K Brennan, T Dale, JM Osborne, DJ Gavaghan, HM Byrne (2017). The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt. PLoS Comp Biol. 13(2): e1005400.
AL MacLean, Z Rosen, HM Byrne, HA Harrington (2015). Parameter-free methods distinguish Wnt pathway models and guide design of experiments. PNAS, 10.1073/pnas.1416655112

Preferred address

Mathematical InstituteUniversity of OxfordOxford OX2 6GG

Prizes, awards, and scholarships

2019: Leah Edelstein-Keshet Prize (Senior Award), Society for Mathematical Biology

2020: Fellow of the Society for Mathematical Biology

Recent publications

The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia.

Chulián, S Stolz, B Martínez-Rubio, Á Blázquez Goñi, C Rodríguez Gutiérrez, J Caballero Velázquez, T Molinos Quintana, Á Ramírez Orellana, M Castillo Robleda, A Fuster Soler, J Minguela Puras, A Martínez Sánchez, M Rosa, M Pérez-García, V Byrne, H PLoS Comput Biol volume 19 issue 8 e1011329- (14 Aug 2023)

Computational modelling of angiogenesis: The importance of cell
rearrangements during vascular growth

Stepanova, D Byrne, H Maini, P Alarcón, T (18 Jul 2023) http://arxiv.org/abs/2307.10297v1

Investigating the influence of growth arrest mechanisms on tumour responses to radiotherapy

Colson, C Maini, P Byrne, H Bulletin of Mathematical Biology volume 85 (28 Jun 2023)

Corrigendum to "A DNA-structured mathematical model of cell-cycle progression in cyclic hypoxia" [J. Theor. Biol. 545 (2022) 111104].

Celora, G Bader, S Hammond, E Maini, P Pitt-Francis, J Byrne, H Journal of theoretical biology volume 571 111507- (05 Jun 2023)

Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration

Martinson, W McLennan, R Teddy, J McKinney, M Davidson, L Baker, R Byrne, H Kulesa, P Maini, P eLife volume 12 (19 Apr 2023)

Teaching

M5: Multivariable calculus
B5.2: Applied Partial Differential Equations
B5.5: Further Mathematical Biology

Research interests

My research focuses on the development and analysis of mathematical and computational models that describe biomedical systems, with particular application to the growth and treatment of solid tumours, wound healing and tissue engineering. My aims in studying such models are two-fold: to identify the mechanisms responsible for observed biomedical phenomena and to abstract from the resulting mathematical models novel features that merit theoretical investigation.