DH 1st floor SR

In recent years, limit order books have been adopted as the pricing mechanism in more than half of the world's financial markets. Thanks to recent technological advances, traders around the globe also now have real-time access to limit order book trading platforms and can develop trading strategies that make use of this "ultimate microscopic level of description". In this talk I will briefly describe the limit order book trade-matching mechanism, and explain how the extra flexibility it provides has vastly impacted the problem of how a market participant should optimally behave in a given set of circumstances. I will then discuss the findings from my recent statistical analysis of real limit order book data for spot trades of 3 highly liquid currency pairs (namely, EUR/USD, GBP/USD, and EUR/GBP) on a large electronic trading platform during May and June 2010, and discuss how a number of my findings highlight weaknesses in current models of limit order books.

DNA double strand breaks (DSB) are the most deleterious type of DNA damage induced by ionizing radiation and cytotoxic agents used in the treatment of cancer. When DSBs are formed, the cell attempts to repair the DNA damage through activation of a variety of molecular repair pathways. One of the earliest events in response to the presence of DSBs is the phosphorylation of a histone protein, H2AX, to form γH2AX. Many hundreds of copies of γH2AX form, occupying several mega bases of DNA at the site of each DSB. These large collections of γH2AX can be visualized using a fluorescence microscopy technique and are called ‘γH2AX foci’. γH2AX serves as a scaffold to which other DNA damage repair proteins adhere and so facilitates repair. Following re-ligation of the DNA DSB, the γH2AX is dephosphorylated and the foci disappear.

We have developed a contrast agent, 111In-anti-γH2AX-Tat, for nuclear medicine (SPECT) imaging of γH2AX which is based on an anti-γH2AX monoclonal antibody. This agent allows us to image DNA DSB in vitro in cells, and in in vivo model systems of cancer. The ability to track the spatiotemporal distribution of DNA damage in vivo would have many potential clinical applications, including as an early read-out of tumour response or resistance to particular anticancer drugs or radiation therapy.

The imaging tracer principle states that a contrast agent should not interfere with the physiology of the process being imaged. Therefore, we have investigated the influence of the contrast agent itself on the kinetics of DSB formation, repair and on γH2AX foci formation and resolution and now wish to synthesise these data into a coherent kinetic-dynamic model.

Please note the unusual start-time.

The inverse acoustic obstacle scattering problem, in its most general

form, seeks to determine the nature of an unknown scatterer from knowl-

edge of its far eld or radiation pattern. The problem which is the main

concern here is:

If the scattering cross section, i.e the absolute value of the radiation

pattern, of an unknown scatterer is known determine its shape.

In this talk we explore the problem from a number of points of view.

These include questions of uniqueness, methods of solution including it-

erative methods, the Minkowski problem and level set methods. We con-

clude by looking at the problem of acoustically invisible gateways and its

connections with cloaking

A central challenge in socio-physics is understanding how groups of self-interested agents make collective decisions. For humans many insights in the underlying opinion formation process have been gained from network models, which represent agents as nodes and social contacts as links. Over the past decade these models have been expanded

to include the feedback of the opinions held by agents on the structure of the network. While a verification of these adaptive models in humans is still difficult, evidence is now starting to appear in opinion formation experiments with animals, where the choice that is being made concerns the direction of movement. In this talk I show how analytical insights can be gained from adaptive networks models and how predictions from these models can be verified in experiments with swarming animals. The results of this work point to a similarity between swarming and human opinion formation and reveal insights in the dynamics of the opinion formation process. In particular I show that in a population that is under control of a strongly opinionated minority a democratic consensus can be restored by the addition of

uninformed individuals.

Understanding the fatigue of metals under cyclic loads is crucial for some fields in mechanical engineering, such as the design of wheels of high speed trains and aero-plane engines. Experimentally it has been found that metal fatigue induced by cyclic loads is closely related to a ladder shape pattern of dislocations known as a persistent slip band (PSB). In this talk, a quantitative description for the formation of PSBs is proposed from two angles: 1. the motion of a single dislocation analised by using asymptotic expansions and numerical simulations; 2. the collective behaviour of a large number of dislocations analised by using a method of multiple scales.

 A common way to replace body tissue is via donors, but as the world population is ageing at an unprecedented rate there will be an even smaller supply to demand ratio for replacement parts than currently exists. Tissue engineering is a process in which damaged body tissue is repaired or replaced via the engineering of artificial tissues. We consider one type of this; a two-phase flow through a rotating high-aspect ratio vessel (HARV) bioreactor that contains a porous tissue construct. We extend the work of Cummings and Waters [2007], who considered a solid tissue construct, by considering flow through the porous construct described by a rotating form of Darcy's equations. By simplifying the equations and changing to bipolar variables, we can produce analytic results for the fluid flow through the system for a given construct trajectory. It is possible to calculate the trajectory numerically and couple this with the fluid flow to produce a full description of the flow behaviour. Finally, coupling with the numerical result for the tissue trajectory, we can also analytically calculate the particle paths for the flow which will lead to being able to calculate the spatial and temporal nutrient density.

Cell motility is a crucial part of many biological processes including wound healing, immunity and embryonic development. The interplay between mechanical forces and biochemical control mechanisms make understanding cell motility a rich and exciting challenge for mathematical modelling. We consider the two-phase, poroviscous, reactive flow framework used in the literature to describe crawling cells and present a stripped down version. Linear stability analysis and numerical simulations provide insight into the onset of polarization of a stationary cell and reveal qualitatively distinct families of travelling wave solutions. The numerical solutions also capture the experimentally observed behaviour that cells crawl fastest when the surface they crawl over is neither too sticky nor too slippy.

Motivated by the study of micro-vascular disease, we have been investigating the relationship between the structure of capillary networks and the resulting blood perfusion through the muscular walls of the heart. In order to derive equations describing effective fluid transport, we employ an averaging technique called homogenisation, based on a separation of length scales. We find that the tissue-scale flow is governed by Darcy's Law, whose coefficients we are able to explicitly calculate by averaging the solution of the microscopic capillary-scale equations. By sampling from available data acquired via high-resolution imaging of the coronary capillaries, we automatically construct physiologically-realistic vessel networks on which we then numerically solve our capillary-scale equations. By validating against the explicit solution of Poiseuille flow in a discrete network of vessels, we show that our homogenisation method is indeed able to efficiently capture the averaged flow properties.

This work builds on the foundation laid by Benney & Timson (1980), who

examined the flow near a contact line and showed that, if the contact

angle is 180 degrees, the usual contact-line singularity does not arise.

Their local analysis, however, does not allow one to determine the

velocity of the contact line and their expression for the shape of the

free boundary involves undetermined constants - for which they have been

severely criticised by Ngan & Dussan V. (1984). As a result, the ideas

of Benny & Timson (1980) have been largely forgotten.

The present work shows that the criticism of Ngan & Dussan V. (1984)

was, in fact, unjust. We consider a two-dimensional steady Couette flow

with a free boundary, for which the local analysis of Benney & Timson

(1980) can be complemented by an analysis of the global flow (provided

the slope of the free boundary is small, so the lubrication

approximation can be used). We show that the undetermined constants in

the solution of Benney & Timson (1980) can all be fixed by matching

their local solution to the global one. The latter also determines the

contact line's velocity, which we compute among other characteristics of

the global flow.