Thu, 20 Jun 2019

16:00 - 17:30
L2

A generic construction for high order approximation schemes of semigroups using random grids

Aurélien Alfonsi
(Ecole des Ponts ParisTech)
Abstract

Our aim is to construct high order approximation schemes for general 
semigroups of linear operators $P_{t},t \ge 0$. In order to do it, we fix a time 
horizon $T$ and the discretization steps $h_{l}=\frac{T}{n^{l}},l\in N$ and we suppose
that we have at hand some short time approximation operators $Q_{l}$ such
that $P_{h_{l}}=Q_{l}+O(h_{l}^{1+\alpha })$ for some $\alpha >0$. Then, we
consider random time grids $\Pi (\omega )=\{t_0(\omega )=0<t_{1}(\omega 
)<...<t_{m}(\omega )=T\}$ such that for all $1\le k\le m$, $t_{k}(\omega 
)-t_{k-1}(\omega )=h_{l_{k}}$ for some $l_{k}\in N$, and we associate the approximation discrete 
semigroup $P_{T}^{\Pi (\omega )}=Q_{l_{n}}...Q_{l_{1}}.$ Our main result is the 
following: for any approximation order $\nu $, we can construct random grids $\Pi_{i}(\omega )$ and coefficients 
$c_{i}$, with $i=1,...,r$ such that $P_{t}f=\sum_{i=1}^{r}c_{i} E(P_{t}^{\Pi _{i}(\omega )}f(x))+O(n^{-\nu})$
with the expectation concerning the random grids $\Pi _{i}(\omega ).$ 
Besides, $Card(\Pi _{i}(\omega ))=O(n)$ and the complexity of the algorithm is of order $n$, for any order
of approximation $\nu$. The standard example concerns diffusion 
processes, using the Euler approximation for $Q_l$.
In this particular case and under suitable conditions, we are able to gather the terms in order to produce an estimator of $P_tf$ with 
finite variance.
However, an important feature of our approach is its universality in the sense that
it works for every general semigroup $P_{t}$ and approximations.  Besides, approximation schemes sharing the same $\alpha$ lead to
the same random grids $\Pi_{i}$ and coefficients $c_{i}$. Numerical illustrations are given for ordinary differential equations, piecewise 
deterministic Markov processes and diffusions.

Fri, 08 Mar 2019

14:00 - 15:00
L2

Arrhythmia from dyad to whole-heart: bi-directional coupling between re-entry and spontaneous calcium release

Dr Michael Colman
(Faculty of Biomedical Sciences University of Leeds)
Abstract

The mechanisms underlying the initiation and perpetuation of cardiac arrhythmias are inherently multi-scale: whereas arrhythmias are intrinsically tissue-level phenomena, they have a significant dependence cellular electrophysiological factors. Spontaneous sub-cellular calcium release events (SCRE), such as calcium waves, are a exemplars of the multi-scale nature of cardiac arrhythmias: stochastic dynamics at the nanometre-scale can influence tissue excitation  patterns at the centimetre scale, as triggered action potentials may elicit focal excitations. This latter mechanism has been long proposed to underlie, in particular, the initiation of rapid arrhythmias such as tachycardia and fibrillation, yet systematic analysis of this mechanism has yet to be fully explored. Moreover, potential bi-directional coupling has been seldom explored even in concept.

A major challenge of dissecting the role and importance of SCRE in cardiac arrhythmias is that of simultaneously exploring sub-cellular and tissue function experimentally. Computational modelling provides a potential approach to perform such analysis, but requires new techniques to be employed to practically simulate sub-cellular stochastic events in tissue-scale models comprising thousands or millions of coupled cells.

This presentation will outline the novel techniques developed to achieve this aim, and explore preliminary studies investigating the mechanisms and importance of SCRE in tissue-scale arrhythmia: How do independent, small-scale sub-cellular events overcome electrotonic load and manifest as a focal excitation? How can SCRE focal (and non-focal) dynamics lead to re-entrant excitation? How does long-term re-entrant excitation interact with SCRE to perpetuate and degenerate arrhythmia?

Fri, 22 Feb 2019

11:45 - 13:15
L2

InFoMM CDT Group Meeting

Helen Fletcher, Bogdan Toader, Jessica Williams, Giuseppe Ughi
(Mathematical Institute)
Tue, 12 Jun 2018
14:30
L2

Random graph coloring and the cavity method

Will Perkins
(Birmingham)
Abstract

The last remaining open problem from Erdős and Rényi's original paper on random graphs is the following: for q at least 3, what is the largest d so that the random graph G(n,d/n) is q-colorable with high probability?  A lot of interesting work in probabilistic combinatorics has gone into proving better and better bounds on this q-coloring threshold, but the full answer remains elusive.  However, a non-rigorous method from the statistical physics of glasses - the cavity method - gives a precise prediction for the threshold.  I will give an introduction to the cavity method, with random graph coloring as the running example, and describe recent progress in making parts of the method rigorous, emphasizing the role played by tools from extremal combinatorics.  Based on joint work with Amin Coja-Oghlan, Florent Krzakala, and Lenka Zdeborová.

Mon, 11 Jun 2018
15:45
L2

Moduli stacks of vacua in geometric representation theory

David Ben-Zvi
(University of Texas at Austin)
Abstract

Topological field theories give rise to a wealth of algebraic structures, extending
the E_n algebra expressing the "topological OPE of local operators". We may interpret these algebraic structures as defining (slightly noncommutative) algebraic varieties and stacks, called moduli stacks of vacua, and relations among them. I will discuss some examples of these structures coming from the geometric Langlands program and their applications. Based on joint work with Andy Neitzke and Sam Gunningham. 

Fri, 15 Jun 2018

16:00 - 17:00
L2

Alfio Quarteroni - Mathematical and numerical models for heart function

Alfio Quarteroni
(EPFL Lausanne and Politecnico di Milano)
Abstract

Mathematical models based on first principles can describe the interaction between electrical, mechanical and fluid-dynamical processes occurring in the heart. This is a classical multi-physics problem. Appropriate numerical strategies need to be devised to allow for an effective description of the fluid in large and medium size arteries, the analysis of physiological and pathological conditions, and the simulation, control and shape optimisation of assisted devices or surgical prostheses. This presentation will address some of these issues and a few representative applications of clinical interest.

Fri, 15 Jun 2018

14:00 - 15:00
L2

Entering the cranial vault: imaging the fetal brain with ultrasound

Dr Ana Namburete
(Department of Engineering Science University of Oxford)
Abstract

Ultrasound (US) imaging is one of the first steps in a continuum of pregnancy care. During the fetal period, the brain undergoes dramatic structural changes, many of which are informative of healthy maturation. The resolution of modern US machines enables us to observe and measure brain structures, as well as detect cerebral abnormalities in fetuses from as early as 18 weeks. Recent breakthroughs in machine learning techniques for image analysis introduce opportunities to  develop bespoke methods to track spatial and temporal patterns of fetal brain development. My work focuses on the design of appropriate data-driven techniques to extract developmental information from standard clinical US images of the brain.

 

Subscribe to L2