I shall say some stuff about quasilinear reaction-diffusion equations, motivated by tissue growth in particular.
For many systems (certainly those in biology, medicine and pharmacology) the mathematical models that are generated invariably include state variables that cannot be directly measured and associated model parameters, many of which may be unknown, and which also cannot be measured. For such systems there is also often limited access for inputs or perturbations. These limitations can cause immense problems when investigating the existence of hidden pathways or attempting to estimate unknown parameters and this can severely hinder model validation. It is therefore highly desirable to have a formal approach to determine what additional inputs and/or measurements are necessary in order to reduce or remove these limitations and permit the derivation of models that can be used for practical purposes with greater confidence.
Structural identifiability arises in the inverse problem of inferring from the known, or assumed, properties of a biomedical or biological system a suitable model structure and estimates for the corresponding rate constants and other model parameters. Structural identifiability analysis considers the uniqueness of the unknown model parameters from the input-output structure corresponding to proposed experiments to collect data for parameter estimation (under an assumption of the availability of continuous, noise-free observations). This is an important, but often overlooked, theoretical prerequisite to experiment design, system identification and parameter estimation, since estimates for unidentifiable parameters are effectively meaningless. If parameter estimates are to be used to inform about intervention or inhibition strategies, or other critical decisions, then it is essential that the parameters be uniquely identifiable.
Numerous techniques for performing a structural identifiability analysis on linear parametric models exist and this is a well-understood topic. In comparison, there are relatively few techniques available for nonlinear systems (the Taylor series approach, similarity transformation-based approaches, differential algebra techniques and the more recent observable normal form approach and symmetries approaches) and significant (symbolic) computational problems can arise, even for relatively simple models in applying these techniques.
In this talk an introduction to structural identifiability analysis will be provided demonstrating the application of the techniques available to both linear and nonlinear parameterised systems and to models of (nonlinear mixed effects) population nature.
The ability of biological matter to move and deform itself is facilitated by microscopic out-of-equilibrium processes that convert chemical energy into mechanical work. In many cases, this mechano-chemical activity takes place on effectively two-dimensional domains formed by, for example, multicellular structures like epithelial tissues or the outer surface of eukaryotic cells, the so-called actomyosin cortex.
We will show in the first part of the talk, that the large-scale dynamics and self-organisation of such structures can be captured by the theory of active fluids. Specifically, using a minimal model of active isotropic fluids, we can rationalize the emergence of asymmetric epithelial tissue flows in the flower beetle during early development, and explain cell rotations in the context of active chiral flows and left-right symmetry breaking that occurs as the model organism C. elegans sets up its body plan.
To develop a more general understanding of such processes, specifically the role of geometry, curvature and interactions with the environment, we introduce in the second part a theory of active fluid surfaces and discuss analytical and numerical tools to solve the corresponding momentum balance equations of curved and deforming surfaces. By considering mechanical interactions with the environment and the fully self-organized shape dynamics of active surfaces, these tools reveal novel mechanisms of symmetry breaking and pattern formation in active matter.
Malignant transformation of somatic tissues is an evolutionary process, driven by selection for oncogenic mutations. Understanding when these mutations occur, and how fast mutant cell clones expand can improve diagnostic schemes and therapeutic intervention. However, clonal dynamics are not directly accessible in humans, posing a need for inference approaches to reconstruct the division history in normal and malignant cell clones, and to predict their future evolution. Inspired from population genetics theory, we develop mathematical models to detect imprints of clonal selection in the variant allele frequency distribution measured in a single tissue sample of a homeostatic tissue. I will present the theoretical basis of our approach and inference results for the tissue dynamics in physiological and clonal hematopoiesis, obtained from variant allele frequencies measured by snapshot bulk whole genome sequencing of human bone marrow samples.
Unraveling the intricacies of intracellular signalling through predictive mathematical models holds great promise for advancing precision medicine and enhancing our foundational comprehension of biology. However, navigating the labyrinth of biological mechanisms governing signalling demands a delicate balance between a faithful description of the underlying biology and the practical utility of parsimonious models.
In this talk, I will present methods that enable training of large ordinary differential equation models of intracellular signalling and showcase application of such models to predict sensitivity to anti-cancer drugs. Through illustrative examples, I will demonstrate the application of these models in predicting sensitivity to anti-cancer drugs. A critical reflection on the construction of such models will be offered, exploring the perpetual question of complexity and how intricate these models should be.
Moreover, the talk will explore novel approaches that meld machine learning techniques with mathematical modelling. These approaches aim to harness the benefits of simplistic and unbiased phenomenological models while retaining the interpretability and biological fidelity inherent in mechanistic models.
Motile cells inside living tissues often encounter junctions, where their path branches into several alternative directions of migration. We present a theoretical model of cellular polarization for cells migrating along one-dimensional lines, exhibiting diverse migration modes. When arriving at a symmetric Y-junction and extending protrusions along the different paths that emanate from the junction. The model predicts the spontaneous emergence of deterministic oscillations between competing protrusions, whereby the cellular polarization and growth alternates between the competing protrusions. These predicted oscillations are found experimentally for two different cell types, noncancerous endothelial and cancerous glioma cells, migrating on patterned network of thin adhesive lanes with junctions. Finally we present an analysis of the migration modes of multicellular "trains" along one-dimensional tracks.
I will discuss logarithmic corrections to various CFT partition functions in the context of the AdS4/CFT3 correspondence for theories arising on the worldvolume of M2-branes. I will use four-dimensional gauged supergravity and heat kernel methods and present general expressions for the logarithmic corrections to the gravitational on-shell action or black hole entropy for a number of different supergravity backgrounds. I will outline several subtleties and puzzles in these calculations and contrast them with a similar analysis of logarithmic corrections performed directly in the eleven-dimensional uplift of a given four-dimensional supergravity background. This analysis suggests that four-dimensional supergravity consistent truncations are not the proper setting for studying logarithmic corrections in AdS/CFT. These results have important implications for the existence of scale-separated AdS vacua in string theory and for effective field theory in AdS more generally.
I will show that the massless irreducible representations of the Poincare group are precisely Corrolian field living on I^+. I will also show that the analogous massless irreducible representation of E11 are just the degrees of freedom of maximal supergravity. Finally I will speculate how spacetime could emerge from an underlying fundamental theory.
In this talk I will review how the BV formalism is used in quantizing theories with local gauge symmetries within the framework of perturbative algebraic quantum field theory. The latter is a mathematically rigorous approach to QFT that combines the locality idea going back to Haag and Kastler with Epstein-Glaser renormalization. In my talk I will also show how these methods can also lead to the construction of a factorization algebra.