Eleonora Agostinelli

My research focuses on combining multiscale and multiphase approaches to mathematical modelling of atherosclerosis. I use structured population models, asymptotic techniques and a multiphase framework to understand the dynamics of macrophages and their interactions with extracellular material in early atherosclerotic plaque. I am currently working on discrete-to-continuum approximations of structured mathematical models using asymptotic methods applied to discrete systems. I use discrete boundary layer analysis to understand various asymptotic regions of the state space that appear degenerate. I also focus on models that include cell proliferation, and I am interested in investigating how and under what conditions different proliferation terms upscale to different leading order continuum models.