When: 9th December, 4pm

Where: the Common Room

What: food and drinks, alcoholic and non-alcoholic

Who: you, your friends and your family

Image: Mr Toad's Christmas Party

Anyone for a mince pi? Mathematical modelling of festive foods - Helen Wilson, UCL

Tuesday, 13 Dec 2022, 17:00

In this talk we'll look at a variety of delicious delights through a lens of fluid dynamics and mathematical modelling. From perfect roast potatoes to sweet sauces, mathematics gets everywhere!

Strong cosmic censorship versus Λ - Mihalis Dafermos, University of Cambridge

Friday 2nd December, 4pm, Lecture Theatre 1

Reception afterwards in the Common Room.

Thu, 01 Dec 2022
13:45
L1

2d RCFTs and 3d TQFTs

Palash Singh
Further Information

Junior Strings is a seminar series where DPhil students present topics of common interest that do not necessarily overlap with their own research area. This is primarily aimed at PhD students and post-docs but everyone is welcome.

Detection of astrophysical tau neutrino candidates in IceCube
Abbasi, R Ackermann, M Adams, J Aguilar, J Ahlers, M Ahrens, M Alispach, C Alves, A Amin, N Andeen, K Anderson, T Ansseau, I Anton, G Argüelles, C Axani, S Bai, X Balagopal, A Barbano, A Barwick, S Bastian, B Basu, V Baum, V Baur, S Bay, R Beatty, J Becker, K Becker Tjus, J Bellenghi, C BenZvi, S Berley, D Bernardini, E Besson, D Binder, G Bindig, D Blaufuss, E Blot, S Böser, S Botner, O Böttcher, J Bourbeau, E Bourbeau, J Bradascio, F Braun, J Bron, S Brostean-Kaiser, J Burgman, A Busse, R Campana, M Chen, C Chirkin, D Choi, S Clark, B Clark, K Classen, L Coleman, A Collin, G Conrad, J Coppin, P Correa, P Cowen, D Cross, R Dave, P De Clercq, C DeLaunay, J Dembinski, H Deoskar, K De Ridder, S Desai, A Desiati, P de Vries, K de Wasseige, G de With, M DeYoung, T Dharani, S Diaz, A Díaz-Vélez, J Dujmovic, H Dunkman, M DuVernois, M Dvorak, E Ehrhardt, T Eller, P Engel, R Evans, J Evenson, P Fahey, S Fazely, A Fiedlschuster, S Fienberg, A Filimonov, K Finley, C Fischer, L Fox, D Franckowiak, A Friedman, E Fritz, A Fürst, P Gaisser, T Gallagher, J Ganster, E Garrappa, S Gerhardt, L Ghadimi, A Glauch, T Glüsenkamp, T Goldschmidt, A Gonzalez, J Goswami, S Grant, D Grégoire, T Griffith, Z Griswold, S Gündüz, M Haack, C Hallgren, A Halliday, R Halve, L Halzen, F Ha Minh, M Hanson, K Hardin, J Haungs, A Hauser, S Hebecker, D Helbing, K Henningsen, F Hickford, S Hignight, J Hill, C Hill, G Hoffman, K Hoffmann, R Hoinka, T Hokanson-Fasig, B Hoshina, K Huang, F Huber, M Huber, T Hultqvist, K Hünnefeld, M Hussain, R In, S Iovine, N Ishihara, A Jansson, M Japaridze, G Jeong, M Jones, B Joppe, R Kang, D Kang, W Kang, X Kappes, A Kappesser, D Karg, T Karl, M Karle, A Katz, U Kauer, M Kellermann, M Kelley, J Kheirandish, A Kim, J Kin, K Kintscher, T Kiryluk, J Klein, S Koirala, R Kolanoski, H Köpke, L Kopper, C Kopper, S Koskinen, D Koundal, P Kovacevich, M Kowalski, M Krings, K Krückl, G Kulacz, N Kurahashi, N Kyriacou, A Lagunas Gualda, C Lanfranchi, J Larson, M Lauber, F Lazar, J Leonard, K Leszczyńska, A Li, Y Liu, Q Lohfink, E Lozano Mariscal, C Lu, L Lucarelli, F Ludwig, A Luszczak, W Lyu, Y Ma, W Madsen, J Mahn, K Makino, Y Mallik, P Mancina, S Mariş, I Maruyama, R Mase, K McNally, F Meagher, K Medina, A Meier, M Meighen-Berger, S Merz, J Micallef, J Mockler, D Momenté, G Montaruli, T Moore, R Morse, R Moulai, M Naab, R Nagai, R Naumann, U Necker, J Neer, G Nguyễn, L Niederhausen, H Nisa, M Nowicki, S Nygren, D Pollmann, A Oehler, M Olivas, A O’Sullivan, E Pandya, H Pankova, D Park, N Parker, G Paudel, E Peiffer, P de los Heros, C Philippen, S Pieloth, D Pieper, S Pizzuto, A Plum, M Popovych, Y Porcelli, A Prado Rodriguez, M Price, P Przybylski, G Raab, C Raissi, A Rameez, M Rawlins, K Rea, I Rehman, A Reimann, R Renschler, M Renzi, G Resconi, E Reusch, S Rhode, W Richman, M Riedel, B Robertson, S Roellinghoff, G Rongen, M Rott, C Ruhe, T Ryckbosch, D Rysewyk Cantu, D Safa, I Sanchez Herrera, S Sandrock, A Sandroos, J Santander, M Sarkar, S Satalecka, K Scharf, M Schaufel, M Schieler, H Schlunder, P Schmidt, T Schneider, A Schneider, J Schröder, F Schumacher, L Sclafani, S Seckel, D Seunarine, S Shefali, S Silva, M Smithers, B Snihur, R Soedingrekso, J Soldin, D Spiczak, G Spiering, C Stachurska, J Stamatikos, M Stanev, T Stein, R Stettner, J Steuer, A Stezelberger, T Stokstad, R Strotjohann, N Stuttard, T Sullivan, G Taboada, I Tenholt, F Ter-Antonyan, S Tilav, S Tischbein, F Tollefson, K Tomankova, L Tönnis, C Toscano, S Tosi, D Trettin, A Tselengidou, M Tung, C Turcati, A Turcotte, R Turley, C Twagirayezu, J Ty, B Unger, E Unland Elorrieta, M Usner, M Vandenbroucke, J Eijk, D Eijndhoven, N Vannerom, D Santen, J Verpoest, S Vraeghe, M Walck, C Wallace, A Wandkowsky, N Watson, T Weaver, C Weindl, A Weiss, M Weldert, J Wendt, C Werthebach, J Weyrauch, M Whelan, B Whitehorn, N Wiebe, K Wiebusch, C Williams, D Wolf, M Wood, T Woschnagg, K Wrede, G Wulff, J Xu, X Xu, Y Yanez, J Yoshida, S Yuan, T Zhang, Z European Physical Journal C volume 82 issue 11 1031- (15 Nov 2022)
Fri, 10 Mar 2023

14:00 - 15:00
Virtual

CRISPR-based decoding of disease-associated genomic variants

Prof Richard Sherwood
(Brigham and Womens Hospital Harvard Medical School)
Abstract

The overall goal of the Sherwood lab is to advance genomic and precision medicine applications through high-throughput, multi-disciplinary science. In a shortened talk this past autumn, I described our recent efforts using combined analysis of rare coding variants from the UK Biobank and genome-scale CRISPR-Cas9 knockout and activation screening to improve the identification of genes, coding variants, and non-coding variants whose alteration impacts serum LDL cholesterol (LDL-C) levels.

In this talk, I will discuss our emerging efforts to optimize and employ precision CRISPR techniques such as base editing and prime editing to better understand the impacts of coding and non-coding variation on serum LDL-C levels and coronary artery disease risk. This work involves the development of novel high-throughput screening platforms and computational analysis approaches that have wide applicability in dissecting complex human disease genetics.

Fri, 03 Mar 2023

14:00 - 15:00
Virtual

An agent-based model of the tumour microenvironment

Dr Cicely Macnamara
(School of Mathematics and Statistics University of Glasgow)
Abstract

The term cancer covers a multitude of bodily diseases, broadly categorised by having cells which do not behave normally. Cancer cells can arise from any type of cell in the body; cancers can grow in or around any tissue or organ making the disease highly complex. My research is focused on understanding the specific mechanisms that occur in the tumour microenvironment via mathematical and computational modelling. In this talk I shall present a 3D individual-based force-based model for tumour growth and development in which we simulate the behaviour of, and spatio-temporal interactions between, cells, extracellular matrix fibres and blood vessels. Each agent is fully realised, for example, cells are described as viscoelastic sphere with radius and centre given within the off-lattice model. Interactions are primarily governed by mechanical forces between elements. However, as well as he mechanical interactions we also consider chemical interactions, by coupling the code to a finite element solver to model the diffusion of oxygen from blood vessels to cells, as well as intercellular aspects such as cell phenotypes. 

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