University of Oxford

Multiple scales analysis is a powerful asymptotic technique for problems where the solution depends on two scales of widely different sizes. Standard multiple scales involves the introduction of a macroscale and microscale which are assumed to be independent. A common (and usually acceptable) assumption is that when considering behaviour on the microscale, the macroscale variable can be taken as constant, however there are instances where this assumption is not valid. In this talk, I will explain one such situation, that is, when considering conductive-radiative thermal transfer within a solid matrix with spherical perforations and discuss the appropriate measures when converting the radiative boundary condition into multiple-scales form.
 

Hilbert's fifth problem asks informally what is the difference between Lie groups and topological groups. In 1950s this problem was solved by Andrew Gleason, Deane Montgomery, Leo Zippin and Hidehiko Yamabe concluding that every locally compact topological group is "essentially" a Lie group. In this talk we will show the complete proof of this theorem.

The time bottleneck in the manufacturing process of Besi (company involved in ESGI 149 Innsbruck) is the extraction of undamaged dies from a component wafer. The easiest way for them to speed up this process is to reduce the number of 'selections' made by the robotic arm.  Each 'selection' made by this robotic arm can be thought of as choosing a 2x2 submatix of a large binary matrix, and editing the 1's in this submatrix to be 0's.  The quesiton is: what is the fewest number of 2x2 submatrices required to cover the full matrix, and how can we find this number. This problem can be solved exactly using integer programming methods, although this approach proves to be prohibitively expensive for realistic sizes. In this talk I will describe the approach taken by my team at EGSI 149, as well as directions for further improvement.

This talk is a brief introduction to the analysis of Donaldson theory, a branch of gauge theory. Roughly, this is an area of differential topology that aims to extract smooth structure invariants from the geometry of the space of solutions (moduli space) to a system of partial differential equations: the Yang-Mills equations.

I will start by discussing the differential geometric background required to talk about Yang-Mills connections. This will involve introducing the concepts of principal fibre bundles, connections and curvature. In the second half of the talk I will attempt to convey the flavour of the mathematics used to address technical issues in gauge theory. I plan to do this by presenting a sketch of the proof of Uhlenbeck's compactness theorem, the main technical tool involved in the compactification of the moduli space.

KW states that every finite abelian extension of the rationals is contained in a cyclotomic extension. In a previous talk, this was reduced to considering cyclic extensions of the local fields Q_p of prime power order l^r. When l\neq p, general theory is sufficient, however for l=p, more specific (although not necessarily more abstruse) descriptions become necessary.
I will focus on the simple structure of Q_p's extensions to obstruct the remaining obstructions to KW (and hopefully provoke some interest in local fields in those less familiar). Time-permitting, I will talk about this theorem in the context of class field theory and/or Hilbert's 12th problem.

The Kronecker-Weber theorem states that every finite abelian extension of the rationals is contained in some cyclotomic field. I will present a proof that emphasizes the standard local-global philosophy by first proving it for the p-adics and then deducing the global case.

Many singular stochastic PDEs are expected to be universal objects that govern a wide range of microscopic models in different universality classes. Two notable examples are KPZ and \Phi^4_3. In these cases, one usually finds a parameter in the system, and tunes according to the space-time scale in such a way that the system rescales to the SPDE in the large-scale limit. We justify this belief for a large class of continuous microscopic growth models (for KPZ) and phase co-existence models (for Phi^4_3), allowing microscopic nonlinear mechanisms far beyond polynomials. Aside from the framework of regularity structures, the main new ingredient is a moment bound for general nonlinear functionals of Gaussians. This essentially allows one to reduce the problem of a general function to that of a polynomial. Based on a joint work with Martin Hairer, and another joint work in progress with Chenjie Fan and Jiawei Li. 

In recent years, much attention has been given to single-cell RNA sequencing techniques as they allow researchers to examine the functions and relationships of single cells inside a tissue. In this study, we combine single-cell RNA sequencing data with protein–protein interaction networks (PPINs) to detect active modules in cells of different transcriptional states. We achieve this by clustering single-cell RNA sequencing data, constructing node-weighted PPINs, and identifying the maximum-weight connected subgraphs with an exact Steiner-Tree approach. As a case study, we investigate RNA sequencing data from human liver spheroids but the techniques described here are applicable to other organisms and tissues. The benefits of our novel method are two-fold: First, it allows us to identify important proteins (e.g., receptors) which are not detected from a differential gene-expression analysis as they only interact with proteins that are transcribed in higher levels. Second, we find that different transcriptional states have different subnetworks of the PPIN significantly overexpressed. These subnetworks often reflect known biological pathways (e.g., lipid metabolism and stress response) and we obtain a nuanced picture of cellular function as we can associate them with a subset of all analysed cells.