Mathematical Biology and Ecology seminars take place in room L3 of the Mathematical Institute from 2-3pm on Fridays of odd weeks in full term. You can also join us afterwards for "tea and cakes" at 3pm in the Mathematical Institute Common Room.
A sister seminar series, organised by the Computational Biology Group, takes place in Room L3 of the Mathematical Institute from 2-3pm on Fridays of even weeks in full term.
Influenza viruses infect millions of individuals each year and cause a significant amount of morbidity and mortality. Understanding how the virus spreads within the lung, how efficacious host immune control is, and how each influences acute lung injury and disease severity is critical to combat the infection. We used an integrative model-experiment exchange to establish the dynamical connections between viral loads, infected cells, CD8+ T cells, lung injury, and disease severity. Our model predicts that infection resolution is sensitive to CD8+ T cell expansion, that there is a critical T cell magnitude needed for efficient resolution, and that the rate of T cell-mediated clearance is dependent on infected cell density.
We validated the model through a series of experiments, including CD8 depletion and whole lung histomorphometry. This showed that the infected area of the lung matches the model-predicted infected cell dynamics, and that the resolved area of the lung parallels the relative CD8 dynamics. Additional analysis revealed a nonlinear relation between disease severity, inflammation, and lung injury. These novel links between important host-pathogen kinetics and pathology enhance our ability to forecast disease progression.
The join button will be published on the right (Above the view all button) 30 minutes before the seminar starts (login required).
- Mathematical Biology and Ecology Seminar