Even though most of us tie our shoelaces "wrongly," knots in ropes and filaments have been used as functional structures for millennia, from sailing and climbing to dewing and surgery. However, knowledge of the mechanics of physical knots is largely empirical, and there is much need for physics-based predictive models. Tight knots exhibit highly nonlinear and coupled behavior due to their intricate 3D geometry, large deformations, self-contact, friction, and even elasto-plasticity. Additionally, tight knots do not show separation of the relevant length scales, preventing the use of centerline-based rod models. In this talk, I will present an overview of recent work from our research group, combining precision experiments, Finite Element simulations, and theoretical analyses. First, we study the mechanics of two elastic fibers in frictional contact. Second, we explore several different knotted structures, including the overhand, figure-8, clove-hitch, and bowline knots. These knots serve various functions in practical settings, from shoelaces to climbing and sailing. Lastly, we focus on surgical knots, with a particularly high risk of failure in clinical settings, including complications such as massive bleeding or the unraveling of high-tension closures. Our research reveals a striking and robust power law, with a general exponent, between the mechanical strength of surgical knots, the applied pre-tension, and the number of throws, providing new insights into their operational and safety limits. These findings could have potential applications in the training of surgeons and enhanced control of robotic-assisted surgical devices.