Take a piece of rope and knot it as you wish. When you are done, glue the two extremities together and you will obtain a physical realisation of what mathematicians also call a knot: a simple closed curve in 3-dimensional space. Now, put the knotted rope on a table and take a picture of it from above. It is now a planar projection of your knot. The mathematical equivalent of it is a knot diagram with multiple crossings as shown in the figure.

Social distancing is integral to our lives these days, but distancing also underpins the ordered patterns and arrangements we see all around us in Nature. Oxford Mathematician Priya Subramanian studies the defects in such patterns and shows how they relate to the underlying pattern, i.e. to the distancing itself.

Tissue oxygenation plays a crucial role in the growth of cancerous tumours and their response to treatments. While it may seem intuitive that reducing oxygen delivery to a tumour would be a treatment therapy, low oxygen levels (hypoxia) can significantly reduce the effectiveness of treatments such as radiotherapy and some chemotherapies. Therefore, understanding the dynamics of a tumour's red blood cells - which carry oxygen through the vasculature - is of vital importance.

One of the great puzzles of the current COVID-19 crisis is the observation that older people have a much higher risk of becoming seriously ill. While it is usually commonly accepted that the immune system fails progressively with age, the actual mechanism leading to this effect was not fully understood. In a recent work, Sam Palmer from Oxford Mathematics and his colleagues in Cambridge have proposed a simple and elegant solution to this puzzle.

Mathematical models have been used throughout the COVID-19 pandemic to help plan public health measures. Attention is now turning to how interventions can be removed while continuing to restrict transmission. Predicting the effects of different possible COVID-19 exit strategies is an important current challenge requiring mathematical modelling, but many uncertainties remain.

A set of integers greater than 1 is primitive if no number in the set divides another. Erdős proved in 1935 that the series of $1/(n \log n)$ for $n$ running over a primitive set A is universally bounded over all choices of A. In 1988 he conjectured that the universal bound is attained for the set of prime numbers. In this research case study, Oxford's Jared Duker Lichtman describes recent progress towards this problem:

For thirty years Oxford Mathematician Roger Penrose has challenged one of the key planks of Cosmology, namely the concept of Inflation, now over 40 years old, according to which our universe expanded at an enormous rate immediately after the Big Bang. Instead, fifteen years ago, Penrose proposed a counter-concept of Conformal Cyclic Cosmology by which Inflation is moved to before the Big Bang and which introduces the idea of preceding aeons.

Ben Green and collaborators discover that the well-known "birthday paradox" has its equivalent in the divisors of a typical integer.

"The well-known "birthday paradox'' states that if you have 23 or more people in a room - something difficult to achieve nowadays without a very large room - then the chances are better than 50:50 that some pair of them will share a birthday. If we could have a party of 70 or more people, the chance of this happening rises to 99.9 percent.