Knot theory studies embeddings of the circle into the three dimensional space and the first knot invariant was the Alexander polynomial. The world of quantum invariants started with the milestone discovery of the Jones polynomial and was expanded by Reshetikhin and Turaev’s algebraic construction which starts from a quantum group and leads to link invariants.

Oxford Mathematician Connor Behan discusses the ways in which a free quantum field can be coupled to a spatial boundary. His recent work with Lorenzo di Pietro, Edoardo Lauria and Balt van Rees sheds light on this question using the non-perturbative bootstrap technique.

What takes a mathematician to the Arctic? In short, context. The ice of the Arctic Ocean has been a rich source of mathematical problems since the late 19$^{th}$ century, when Josef Stefan, aided by data from expeditions that went in search of the Northwest Passage, developed the classical Stefan problem. This describes the evolution of a moving boundary at which a material undergoes a phase change. In recent years, interest in the Arctic has only increased, due to the rapid changes occurring there due to climate change.

Deep learning has become an important topic across many domains of science due to its recent success in image recognition, speech recognition, and drug discovery. Deep learning techniques are based on neural networks, which contain a certain number of layers to perform several mathematical transformations on the input.

Oxford Mathematician Ben Green on a tale of conjectures, mistaken assumptions and eventual solutions: a tale of mathematics.

"The famous discrete mathematician Ron Graham sadly passed away last year. I did not know him well, but I had the pleasure of meeting him a few times. On the first such occasion, in Vancouver in 2004, he mentioned one of his favourite open questions over lunch. This concerns the size of certain "van der Waerden numbers", a kind of arithmetic variant of graph Ramsey numbers.

During the early growth of the brain, an extraordinary process takes place where axons, neurons, and nerves extend, grow, and connect to form an intricate network that will be used for all brain activities and cognitive processes. A fundamental scientific question is to understand the laws that these growing cells follow to find their correct target.

By pooling resources between cells, colonies of bacteria can exhibit behaviours far beyond the capabilities of an individual bacterium. For example, bacterial populations can encase themselves in a self-generated polymer matrix that shelters cells in the core of the population from the external environment. Such communities are termed “bacterial biofilms”, and show increased tolerance to antimicrobial treatments such as antibiotics.

How to deal with resistance? This is the headline question these days with regards to COVID vaccines. But it is an important question also in cancer therapy. Over the past century, oncology has come a long way, but all too often cancers still recur due to the emergence of drug-resistant tumour cells. How to tackle these cells is one of the key questions in cancer research. The main strategy so far has been the development of new drugs to which the resistant cells are still sensitive.